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Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation.
Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, Wrana JL
Mol Cell. 2000 Dec . 6(6):1365-75.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
11746pCMV5B-Flag-Smurf2 wt
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11747pCMV5B-Flag-Smurf2 C716A
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13504pGEX4T1-Smurf2 wt
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13505pGEX4T1-Smurf2 C716A
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Recombinant Antibodies from Article