Addgene - Robert Lefkowitz Lab Plasmids

The Robert Lefkowitz Lab has deposited plasmids at Addgene for distribution to academic researchers. Addgene is a non-profit plasmid repository dedicated to improving life science research.

Learn more about research in the Robert Lefkowitz Lab.

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Title	Authors
A stress response pathway regulates DNA damage through beta2-adrenoreceptors and beta-arrestin-1.	Hara et al
The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2.	Nobles et al
Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins.	Nelson et al
G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer.	Violin et al
beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.	Shenoy et al
Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes.	Shenoy et al
Activation-dependent conformational changes in {beta}-arrestin 2.	Xiao et al
Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor.	Ahn et al
Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases.	Pitcher et al
Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor.	Tang et al
The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis.	Laporte et al
Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.	Luttrell et al
Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies.	Pitcher et al
Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants.	Premont et al
Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling.	Koch et al
Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase.	Freedman et al