Hot Plasmids - May 2022
Type
Blog Post
... of the AAV capsids (left) and transduction patterns (right). Both AAV-PHP.eB and the AAV.CAP-B capsids...Increased neuronal expression using Cre-mediated AAV Targeted Evolution method (M-CREATE)
dCas9-SSAP with...Increased neuronal expression using Cre-mediated AAV Targeted Evolution method (M-CREATE)
by: Brian O'...developed the multiplexed version of the Cre-mediated AAV Targeted Evolution method (M-CREATE), in which one...this system could potentially be packaged into an AAV system. dCas9-SSAP will make the editing of kilobase-scaled...capsids are derived from AAV9. Of those shown here, only AAV.CAP-B10 causes brain wide expression, with ...is true in both mice and nonhuman primates (for AAV.CAP-B10, for example). Given that the liver is an ...