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We narrowed to 30 results for: AAV9

Showing: 1 - 20 of 30 results

  1. New Viral Vectors - March 2024

    Type
    Blog Post
    Published
    March 5, 2024, 2:15 p.m.
    ...AAV-mDlx-jGCaMP8s-WPRE  AAV9 Biosensor Looger New serotype AAV-hSyn-Soma-jGCaMP8s AAV9 Biosensor Fyhn New...AAV-hSyn-Soma-jGCaMP8f AAV9 Biosensor Fyhn New serotype pAAV-hSyn-JEDI-2P-Kv-WPRE AAV9 Biosensor St-Pierre...pAAV-hSyn-JEDI-2P-WPRE AAV9 Biosensor St-Pierre New viral vector pAAV-CAG-RdLight1 AAV9 Biosensor Tian New...pAAV-hSynapsin1-RdLight1 AAV9 Biosensor Tian New viral vector pAAV_hSynapsin_psychLight2 AAV9 Biosensor Tian ...pAAV.hSynapsin.SF-iGluSnFR.A184S AAV9 Biosensor Looger New serotype pAAV-CAG-DIO-NLS-mRuby3-IRES-eGtACR1-ST AAV9 Optogenetics...interest is the Tian lab's pAAV_hSynapsin_psychLight2 (AAV9), which contains a biosensor that detects both serotonin...

  2. New Viral Vectors - Summer 2024

    Type
    Blog Post
    Published
    July 9, 2024, 1:15 p.m.
    ...pAAV_hSyn1_nLightG AAV9 Biosensors Patriarchi New viral service pAAV_hSyn1_nLightR AAV9 Biosensors Patriarchi... AAV1, AAV9 Biosensors Li New viral service with multiple serotypes pAAV-hSyn-GRAB_OTmut AAV9 Biosensors...pAAV-hSyn-GRAB_ACh3.0 AAV9 Biosensors Li New viral service pAAV-Ef1a-fDIO-ChrimsonR-tdTomato AAV9 Controls Jensen...serotype pAAV-CAG-2xNLS-tdTomato-WPRE-hGHpolyA AAV9, PHP.eB Controls Feng New viral service, multiple...

  3. Viral Vectors 101: Systemic Capsids

    Type
    Blog Post
    Published
    Oct. 12, 2023, 1:15 p.m.
    ...astrocytes (60%) than AAV9 (Ravindra Kumar et al., 2020). AAV9-X1.1 is evolved from AAV9 and transduces GLUT1...capsids are derived from AAV9, their efficacy is generally compared to the AAV9 serotype or an engineered...expression, compared to AAV9, in BALB/cJ mice but is more effective than AAV9 in many other strains, including... efficiency than AAV9 and thus produces lower viral yields. AAV-F, derived from AAV9 using iTransduce,...from variable region VIII of AAV9-X1.1 to that of AAV1. AAV1-X1 reproduces AAV9-X1.1’s brain endothelial ...AAV.CAP-Mac has a lower transduction rate than AAV9 in the liver. AAV9-X1.1 effectively and predominantly transduces...respectively) relative to AAV9 in the pigtail macaque brain slices. Similarly, AAV9-X1.1 outperformed the ...

  4. New Viral Vectors - Fall 2024

    Type
    Blog Post
    Published
    Oct. 3, 2024, 1:15 p.m.
    ...first Addgene prep packaged in the AAV9-X1.1 serotype.  In rodents, AAV9-X1.1 enables expression in brain...levels compared to AAV9. You can now target these cells with AAV-CAG-GFP packaged in AAV9-X1.1!  We also ...Recombinases Jonathan Ting New viral prep pAAV-CAG-GFP AAV9-X1.1 Controls Edward Boyden New serotype pAAV-...Loren Looger New serotype pAAV-CAG-FLEx-iSeroSnFR AAV9 Biosensors Lin Tian New viral prep pAAV-hSyn-GRAB-gDA3m...

  5. Beyond the Blood Brain Barrier: PHP.B Enters the Central Nervous System Via the LY6A Receptor

    Type
    Blog Post
    Published
    July 23, 2019, 12:46 p.m.
    ... CNS. PHP.B, a neurotropic variant of AAV9, is better than AAV9 at gaining access to the CNS of C57BL/...diverse library of AAV9 mutants that had a small randomized peptide loop inserted in the AAV9 capsid. This ...adeno-associated virus (AAV), from reaching their targets. The AAV9 serotype can breach the BBB following injection ...by PHP.B viruses. Creating PHP.B, a neurotropic AAV9 variant PHP.B’s specificity for C57BL/6J mice is...reached the CNS following IV injection. Compared to AAV9, PHP.B has a >40-fold increase in CNS transduction....B required the same receptors that its parental AAV9 relied on for transducing cells: galactose and the...results suggested that PHP.B, unlike its parental AAV9, does not require galactose and AAVR to transduce...

  6. New and Upcoming Viral Vectors - December 2019

    Type
    Blog Post
    Published
    Dec. 19, 2019, 2:40 p.m.
    ...Name 113050 AAV9, AAVrg pAAV-hSyn-GRAB_DA1h 113049 AAV9 pAAV-hSyn-GRAB_DA1m 123308 AAV9, AAVrg pAAV-hSyn-GRAB_NE1m...Serotype Name 124603 AAV9 pAAV-EF1a-DIO-ChrimsonR-mRuby2-KV2.1-WPRE-SV40 124650 AAV9 pAAV-CamKIIa-C1V1(...readily available to the community. We now offer AAV9 for 2 more constructs from Christopher Harvey’s ...

  7. New and Upcoming Viral Vectors - June 2019

    Type
    Blog Post
    Published
    June 18, 2019, 1:15 p.m.
    ...axon-GCaMP6s 112005  AAV9 pAAV-hSynapsin1-axon-GCaMP6s-P2A-mRuby3) 112010  AAV9 pAAV-hSynapsin1-FLEx-axon-GCaMP6s...Serotype Name 124651  AAV9  pAAV-CamKIIa-ChrimsonR-mScarlet-KV2.1 124603  AAV9  pAAV-EF1a-DIO-ChrimsonR-mRuby2... 114472  AAV5, AAV8 pAAV-hSyn-mCherry 50459  AAV9, AAVrg pAAV-hSyn-DIO-mCherry 37825 AAV1, 2, 5,...

  8. Viral Vectors 101: AAV Serotypes and Tissue Tropism

    Type
    Blog Post
    Published
    Jan. 16, 2025, 2:15 p.m.
    ...AAVrg), AAV5, AAV8, AAV9, AAV11 Heart AAV1, AAV8, AAV9 Kidney AAV8 Liver AAV8, AAV9 Lung AAV6 Pancreas...Issa et al., 2023; Wu, Asokan, et al., 2006). AAV9 AAV9 has relatively broad tissue tropism and high transduction...Carboxypeptidase D (CPD), also called AAVR25   AAV9 Terminal N-linked galactose3 AAV receptor (AAVR...retro (AAVrg) ✓ ✓ AAV5 ✓ ✓ AAV6 ✓ ✓ AAV8 ✓ ✓ AAV9 ✓   AAV11 ✓ ✓ AAV1 AAV1 was the first viral...targeting the CNS (Issa et al., 2023). Additionally, AAV9 has been shown to transduce liver, skeletal muscle...cells AAV2, AAV5, AAV8 Skeletal muscle AAV1, AAV8, AAV9 In addition to tissue tropism, different AAV...

  9. Important Considerations When Using AAVs

    Type
    Blog Post
    Published
    June 13, 2017, 2:30 p.m.
    ...AAV4, AAV5, AAV8, AAV9 Heart AAV1, AAV8, AAV9 Kidney AAV2 Liver AAV7, AAV8, AAV9 Lung AAV4, AAV5...AAV5>AAV9>AAV8>AAV1>AAV6>AAV2 Hippocampus AAV9>AAV5>AAV8>AAV1>AAV6>AAV2 Auditory Cortex AAV9>AAV8>...AAV5, AAV6, AAV9 Pancreas AAV8 Photoreceptor Cells AAV2, AAV5, AAV8 RPE (Retinal Pigment Epithelium..., AAV8 Skeletal Muscle AAV1, AAV6, AAV7, AAV8, AAV9 Adapted from https://www.addgene.org/viral-vectors... Oligodendrocytes AAV8 > AAV2 & AAV6 Microglia AAV9 > AAV2 & AAV6 Astrocytes AAV8 > AAV2 & AAV6 ...

  10. Hot Plasmids February 2024

    Type
    Blog Post
    Published
    Feb. 20, 2024, 2:45 p.m.
    ...potency of AAV-PHP.eB.    Figure 4: AAV9-X1 and AAV9-X1.1 efficiently transduce brain endothelial...multispecies approach to generate and screen a library of AAV9 variants (Chuapoco et al., 2023). They found the...human neurons, with broader neuronal expression than AAV9. This new capsid will be a valuable tool for investigating...-mer peptide region from variable region VIII of AAV9-X1.1 to that of AAV1. This viral vector has brain...not neutralized by pre-existing antibodies against AAV9-based vectors (and vice versa), enabling repeat ...

  11. New and Upcoming Viral Vectors - September 2019

    Type
    Blog Post
    Published
    Sept. 12, 2019, 1 p.m.
    ...AAV in AAV9 and AAVrg. See our new additions here: Cre vectors pAAV-EF1a-fDIO-Cre (121675-AAV9, 121675...available as 20 ul aliquots in AAV1, AAV2, AAV5, AAV8, AAV9, and AAV Retrograde. You can also request the specific...” pAAV-CamKIIa-ChrimsonR-mScarlet-KV2.1 (124651-AAV9) Recombinase AAV Targeting and manipulating specific...

  12. Using AAV for Neuronal Tracing

    Type
    Blog Post
    Published
    Aug. 9, 2018, 1:04 p.m.
    ...AAV5, AAV8, AAV9 Heart AAV1, AAV8, AAV9 Liver AAV7, AAV8, AAV9 Lung AAV4, AAV5, AAV6, AAV9 RPE (Retinal...to be the case for either AAV1 or AAV9. It should be noted that AAV9 was shown to cross the blood brain..., AAV8 Skeletal Muscle AAV1, AAV6, AAV7, AAV8, AAV9 Table 1: Common AAV Serotypes and their target...networks. Kohara et al. 2014 traced neurons with an AAV9 vector expressing a Cre-dependent fluorescent marker... et al. 2017 also provide evidence that AAV1 and AAV9 are capable of synaptic spread. The underlying mechanisms...Chan, C.M. and Kaspar B.K. (2009). Intravascular AAV9 preferentially targets neonatal neurons and adult...

  13. New and Upcoming Viral Vectors - Spring 2019

    Type
    Blog Post
    Published
    March 26, 2019, 1:40 p.m.
    ...codon diversified) 37825  AAV8*, AAV9*  pAAV-CAG-GFP 50465  AAV8*, AAV9*  pAAV-hSyn-EGFP *Also coming... 50363  AAV5  AAV phSyn1(S)-DreO-bGHpA 121675  AAV9  pAAV-EF1a-fDIO-Cre (FLP-dependent CRE) 55634 ...

  14. Newly Updated AAV Data Hub!

    Type
    Blog Post
    Published
    Feb. 7, 2023, 2:15 p.m.
    ...combined with a Cre-dependent AAV9 tdTomato virus in the mPFC.  The AAV9 is so strong that you can even...

  15. Hot Biosensors 2022: Year-End Roundup

    Type
    Blog Post
    Published
    Dec. 6, 2022, 2:15 p.m.
    ...axon-GCaMP6s-P2A-mKate2 (AAV9) pAAV-hSynapsin1-GCaMP6s-P2A-mKate2 (AAV9) pAAV-hSynapsin1-GCaMP6s-P2A-mRuby3 (AAV9) pAAV-...pAAV-CAG-SomaGCaMP6f2 (AAV9) Plus, additional AAV serotypes of the most recent jGCaMP8 calcium sensors: ...

  16. AAV Q&A with Tim Miles

    Type
    Blog Post
    Published
    May 17, 2022, 1:15 p.m.
    ...recommend using one of the natural serotypes such as AAV9 or AAV8. Very recently an engineered AAV5 capsid... of our engineered AAV are presently built on an AAV9 backbone and so will very likely cross-react with...

  17. Negative Can Be Positive: Open AAV Data with Addgene

    Type
    Blog Post
    Published
    Sept. 6, 2022, 1:15 p.m.
    ...shown) were not good options while AAV8 (82%) and AAV9 (84%) were both excellent at infecting our target... Variation in Adeno-Associated Virus Serotype 9 (AAV9) Preparations. Human Gene Therapy Methods, 30(6)...

  19. Viral Vectors 101: AAV Variables That Matter

    Type
    Blog Post
    Published
    June 1, 2023, 1:15 p.m.
    ...transmission (Oh et al., 2020). For example, AAV1 and AAV9 tend to spread farther from the injection site than...anterogradely along the axon. Others, like AAV1 and AAV9, can also transduce postsynaptic cells when used...

  20. Hot Plasmids and Viral Preps - July 2021

    Type
    Blog Post
    Published
    July 27, 2021, 1:15 p.m.
    ...expanded. Check out the new selection of ready-to-use AAV9 and AAVrg vectors. New red-shifted INTRSECT 2.0 ...
Showing: 1 - 20 of 30 results