Mouse Modeling, Part 1: Genetically Engineered Mice
Type
Blog Post
Published
July 11, 2019, 1:26 p.m.
...vector. CRISPR/Cas9-based systems have been developed for generating knockin mice but because CRISPR/Cas9...recombination for precise gene insertion. However, CRISPR/Cas9 systems are more useful for generating knockout...used to engineer knockout mice. ZFN, TALEN, and CRISPR/Cas9 systems can all be targeted to specific regions...can introduce multiple base pair deletions, but CRISPR/Cas9 can also introduce point mutations.
While ...Additional resources on the Addgene blog
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