PIK3CA-WT Citations (10)
Originally described in: High frequency of mutations of the PIK3CA gene in human cancers.Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE Science. 2004 Apr 23. 304(5670):554. PubMed Journal
Articles Citing PIK3CA-WT
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| Mutant PIK3CA controls DUSP1-dependent ERK 1/2 activity to confer response to AKT target therapy. Sathe A, Guerth F, Cronauer MV, Heck MM, Thalgott M, Gschwend JE, Retz M, Nawroth R. Br J Cancer. 2014 Nov 25;111(11):2103-13. doi: 10.1038/bjc.2014.534. Epub 2014 Nov 4. PubMed |
| The E545K mutation of PIK3CA promotes gallbladder carcinoma progression through enhanced binding to EGFR. Zhao S, Cao Y, Liu SB, Wang XA, Bao RF, Shu YJ, Hu YP, Zhang YJ, Jiang L, Zhang F, Liang HB, Li HF, Ma Q, Xu Y, Wang Z, Zhang YC, Chen L, Zhou J, Liu YB. J Exp Clin Cancer Res. 2016 Jun 18;35(1):97. doi: 10.1186/s13046-016-0370-7. PubMed |
| Targeted therapy in patients with PIK3CA-related overgrowth syndrome. Venot Q, Blanc T, Rabia SH, Berteloot L, Ladraa S, Duong JP, Blanc E, Johnson SC, Hoguin C, Boccara O, Sarnacki S, Boddaert N, Pannier S, Martinez F, Magassa S, Yamaguchi J, Knebelmann B, Merville P, Grenier N, Joly D, Cormier-Daire V, Michot C, Bole-Feysot C, Picard A, Soupre V, Lyonnet S, Sadoine J, Slimani L, Chaussain C, Laroche-Raynaud C, Guibaud L, Broissand C, Amiel J, Legendre C, Terzi F, Canaud G. Nature. 2018 Jun;558(7711):540-546. doi: 10.1038/s41586-018-0217-9. Epub 2018 Jun 13. PubMed |
| Nimbolide, a neem limonoid inhibits cytoprotective autophagy to activate apoptosis via modulation of the PI3K/Akt/GSK-3beta signalling pathway in oral cancer. Sophia J, Kowshik J, Dwivedi A, Bhutia SK, Manavathi B, Mishra R, Nagini S. Cell Death Dis. 2018 Oct 23;9(11):1087. doi: 10.1038/s41419-018-1126-4. PubMed |
| Phosphatidylinositol-3-kinase (PI3K)/Akt Signaling is Functionally Essential in Myxoid Liposarcoma. Trautmann M, Cyra M, Isfort I, Jeiler B, Kruger A, Grunewald I, Steinestel K, Altvater B, Rossig C, Hafner S, Simmet T, Becker J, Aman P, Wardelmann E, Huss S, Hartmann W. Mol Cancer Ther. 2019 Apr;18(4):834-844. doi: 10.1158/1535-7163.MCT-18-0763. Epub 2019 Feb 20. PubMed |
| Downregulation of miR-223 expression is an early event during mammary transformation and confers resistance to CDK4/6 inhibitors in luminal breast cancer. Citron F, Segatto I, Rampioni Vinciguerra GL, Musco L, Russo F, Mungo G, D'Andrea S, Mattevi MC, Perin T, Schiappacassi M, Massarut S, Marchini C, Amici A, Vecchione A, Baldassarre G, Belletti B. Cancer Res. 2019 Dec 20. pii: 0008-5472.CAN-19-1793. doi: 10.1158/0008-5472.CAN-19-1793. PubMed |
PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS.
Nieuwenhuis B, Barber AC, Evans RS, Pearson CS, Fuchs J, MacQueen AR, van Erp S, Haenzi B, Hulshof LA, Osborne A, Conceicao R, Khatib TZ, Deshpande SS, Cave J, Ffrench-Constant C, Smith PD, Okkenhaug K, Eickholt BJ, Martin KR, Fawcett JW, Eva R.
EMBO Mol Med. 2020 Aug 7;12(8):e11674. doi: 10.15252/emmm.201911674. Epub 2020 Jun 17.
PubMed
Associated Plasmids |
| KRASQ61H preferentially signals through MAPK in a RAF dimer-dependent manner in non-small cell lung cancer. Zhou ZW, Ambrogio C, Bera AK, Li Q, Li XX, Li L, Son J, Gondi S, Li J, Campbell E, Jin H, Okoro JJ, Xu CX, Janne PA, Westover KD. Cancer Res. 2020 Jun 30. pii: 0008-5472.CAN-20-0448. doi: 10.1158/0008-5472.CAN-20-0448. PubMed |
| Regulation of Chemosensitivity in Human Medulloblastoma Cells by p53 and the PI3 Kinase Signaling Pathway. Naeem A, Harish V, Coste S, Parasido EM, Choudhry MU, Kromer LF, Ihemelandu C, Petricoin EF, Pierobon M, Noon MS, Yenugonda VM, Avantaggiati M, Kupfer GM, Fricke S, Rodriguez O, Albanese C. Mol Cancer Res. 2022 Jan;20(1):114-126. doi: 10.1158/1541-7786.MCR-21-0277. Epub 2021 Oct 11. PubMed |
| miRNA-193b-5p Suppresses Pancreatic Cancer Cell Proliferation, Invasion, Epithelial Mesenchymal Transition, and Tumor Growth by Inhibiting eEF2K. Gurbuz N, Kahraman N, Sonmez HE, Mokhlis HA, Kosar PA, Ozpolat B. Anticancer Agents Med Chem. 2022;22(14):2607-2618. doi: 10.2174/1871520622666220117123213. PubMed |
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