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Bruce Conklin Lab Plasmids


The Bruce Conklin Lab has deposited plasmids at Addgene for distribution to the research community. Addgene is a non-profit plasmid repository dedicated to improving life science research.

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Title Authors Publication
Alternative splicing regulates mouse embryonic stem cell pluripotency and differentiation. Salomonis N, Schlieve CR, Pereira L, Wahlquist C, Colas A, Zambon AC, Vranizan K, Spindler MJ, Pico AR, Cline MS, Clark TA, Williams A, Blume JE, Samal E, Mercola M, Merrill BJ, Conklin BR Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10514-9. Epub 2010 May 24.
Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass. Hsiao EC, Boudignon BM, Chang WC, Bencsik M, Peng J, Nguyen TD, Manalac C, Halloran BP, Conklin BR, Nissenson RA Proc Natl Acad Sci U S A. 2008 Jan 29. 105(4):1209-14.
Engineered G protein coupled receptors reveal independent regulation of internalization, desensitization and acute signaling. Scearce-Levie K, Lieberman MD, Elliott HH, Conklin BR BMC Biol. 2005 . 3():3.
Controlling signaling with a specifically designed Gi-coupled receptor. Coward P, Wada HG, Falk MS, Chan SD, Meng F, Akil H, Conklin BR. Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):352-7.
Carboxyl-terminal mutations of Gq alpha and Gs alpha that alter the fidelity of receptor activation. Conklin BR, Herzmark P, Ishida S, Voyno-Yasenetskaya TA, Sun Y, Farfel Z, Bourne HR Mol Pharmacol. 1996 Oct . 50(4):885-90.
Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha. Conklin BR, Farfel Z, Lustig KD, Julius D, Bourne HR Nature. 1993 May 20. 363(6426):274-6.
Conklin Lab TALEN plasmids (unpublished)
RO1 (unpublished)
ID Plasmid Gene/Insert Vector Type Publication Hidden Extra Search Info  
16312 pUNIV-SIG-5HTR4D100A h5HT4b Serotonin Receptor (Rs1 D100A RASSL) (Homo sapiens) Mammalian Expression Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass. Proc Natl Acad Sci U S A. 2008 Jan 29. 105(4):1209-14. pUNIV HTR4 5-HT4, 5-HT4R Add to Cart
16313 pUHG10.3-TetO-Rs1 h5HT4b Serotonin Receptor (Rs1 D100A RASSL) (Homo sapiens) Mammalian Expression Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass. Proc Natl Acad Sci U S A. 2008 Jan 29. 105(4):1209-14. pUHG10-3 RS1 RP1-245G19.1, RS, XLRS1 Add to Cart
24429 pcDNA3-Rog RASSL (Homo sapiens) Mammalian Expression Engineered G protein coupled receptors reveal independent regulation of internalization, desensitization and acute signaling. BMC Biol. 2005 . 3():3. pcDNA3 OPRK1 KOR, OPRK Add to Cart
24498 qs5 Gq alpha (Mus musculus) Mammalian Expression Carboxyl-terminal mutations of Gq alpha and Gs alpha that alter the fidelity of receptor activation. Mol Pharmacol. 1996 Oct . 50(4):885-90. pcDNA1 Gnaq 1110005L02Rik, 6230401I02Rik, AA408290, AW060788, Dsk1, Dsk10, Galphaq, Gq, GqI Add to Cart
24499 sq5 Gs alpha (Rattus norvegicus) Mammalian Expression Carboxyl-terminal mutations of Gq alpha and Gs alpha that alter the fidelity of receptor activation. Mol Pharmacol. 1996 Oct . 50(4):885-90. pcDNA1 Gnas Gnas1, Gnpas, Nesp55 Add to Cart
24500 qo5 Gq alpha (Mus musculus) Mammalian Expression Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha. Nature. 1993 May 20. 363(6426):274-6. pcDNA1 Gnaq 1110005L02Rik, 6230401I02Rik, AA408290, AW060788, Dsk1, Dsk10, Galphaq, Gq, GqI Add to Cart
24501 qi5 Gq alpha (Mus musculus) Mammalian Expression Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha. Nature. 1993 May 20. 363(6426):274-6. pcDNA1 Gnaq 1110005L02Rik, 6230401I02Rik, AA408290, AW060788, Dsk1, Dsk10, Galphaq, Gq, GqI Add to Cart
24502 q4wt Gq alpha (Mus musculus) Mammalian Expression Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha. Nature. 1993 May 20. 363(6426):274-6. pcDNA1 Add to Cart
24503 pcDNA3-Ro2 RASSL Ro2 (Homo sapiens) Mammalian Expression Controlling signaling with a specifically designed Gi-coupled receptor. Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):352-7. pcDNA3 OPRK1 KOR, OPRK Add to Cart
24504 pcDNA3-Ro1 RASSL Ro1 (Homo sapiens) Mammalian Expression RO1 (unpublished) pcDNA3 OPRK1 KOR, OPRK Add to Cart
25867 qz5 Gq alpha (Mus musculus) Mammalian Expression Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha. Nature. 1993 May 20. 363(6426):274-6. pcDNA1 Gnaq 1110005L02Rik, 6230401I02Rik, AA408290, AW060788, Dsk1, Dsk10, Galphaq, Gq, GqI Add to Cart
31845 pSicoR-Ef1a-mCh-Puro Mammalian Expression, Lentiviral, RNAi, Cre/Lox Alternative splicing regulates mouse embryonic stem cell pluripotency and differentiation. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10514-9. Epub 2010 May 24. pSicoR-mCH Add to Cart
31847 pSicoR-Ef1a-mCh Mammalian Expression, Lentiviral, RNAi, Cre/Lox Alternative splicing regulates mouse embryonic stem cell pluripotency and differentiation. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10514-9. Epub 2010 May 24. pSicoR-mCH Add to Cart
31848 pSicoR-Ef1a-mCh-Puro-GFPi GFP RNAi Mammalian Expression, Lentiviral, RNAi, Cre/Lox Alternative splicing regulates mouse embryonic stem cell pluripotency and differentiation. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10514-9. Epub 2010 May 24. pSicoR-Ef1a-mCH-Puro Add to Cart
31849 pSicoR-Ef1a-mCh-GFPi GFP RNAi Mammalian Expression, Lentiviral, RNAi, Cre/Lox Alternative splicing regulates mouse embryonic stem cell pluripotency and differentiation. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10514-9. Epub 2010 May 24. pSicoR-Ef1a-mCh Add to Cart
31850 pSicoR-Ef1a-mCh-Puro-Luci Luciferase RNAi Mammalian Expression, Lentiviral, RNAi, Cre/Lox Alternative splicing regulates mouse embryonic stem cell pluripotency and differentiation. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10514-9. Epub 2010 May 24. pSicoR-Ef1a-mCH-Puro Add to Cart
49449 MR015-PHOX2BRightTALEN_NN TALEN (Other) Mammalian Expression, TALEN Conklin Lab TALEN plasmids (unpublished) Right TALEN for PHOX2B with NN MR015 Add to Cart
49450 MR015-PHOX2BLeftTALEN_NN TALEN (Other) Mammalian Expression, TALEN Conklin Lab TALEN plasmids (unpublished) Left TALEN for PHOX2B with NN MR015 Add to Cart
49451 MR015-PKP2 Left TALEN_NN TALEN (Other) Mammalian Expression, TALEN Conklin Lab TALEN plasmids (unpublished) Left TALEN for PKP2 with NN MR015 Add to Cart
49452 MR015-PKP2 Right TALEN_NN TALEN (Other) Mammalian Expression, TALEN Conklin Lab TALEN plasmids (unpublished) Right TALEN for PKP2 with NN MR015 Add to Cart
49453 MR015-PRKAG2 Left TALEN TALEN (Other) Mammalian Expression, TALEN Conklin Lab TALEN plasmids (unpublished) Left TALEN for PRKAG2 MR015 Add to Cart
49454 MR015-PRKAG2 Right TALEN TALEN (Other) Mammalian Expression, TALEN Conklin Lab TALEN plasmids (unpublished) Right TALEN for PRKAG2 MR015 Add to Cart
49465 MR015-BAG3 Left TALEN TALEN (Other) Mammalian Expression, TALEN Conklin Lab TALEN plasmids (unpublished) Left TALEN for BAG3 MR015 Add to Cart
49466 MR015-BAG3 Right TALEN TALEN (Other) Mammalian Expression, TALEN Conklin Lab TALEN plasmids (unpublished) Right TALEN for BAG3 MR015 Add to Cart
49477 MR015-PHOX2BLeftTALEN_NK TALEN (Other) Mammalian Expression, TALEN Conklin Lab TALEN plasmids (unpublished) Left TALEN for PHOX2B with NK MR015 Add to Cart
49478 MR015-PHOX2BRightTALEN_NK TALEN (Other) Mammalian Expression, TALEN Conklin Lab TALEN plasmids (unpublished) Right TALEN for PHOX2B with NK MR015 Add to Cart
49479 MR015-PKP2 Left TALEN_NK TALEN (Other) Mammalian Expression, TALEN Conklin Lab TALEN plasmids (unpublished) Left TALEN for PKP2 with NK MR015 Add to Cart
49480 MR015-PKP2 Right TALEN_NK TALEN (Other) Mammalian Expression, TALEN Conklin Lab TALEN plasmids (unpublished) Right TALEN for PKP2 with NK MR015 Add to Cart