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Tyler Jacks Lab Plasmids


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Title Authors Publication
Rapid modelling of cooperating genetic events in cancer through somatic genome editing. Sanchez-Rivera FJ, Papagiannakopoulos T, Romero R, Tammela T, Bauer MR, Bhutkar A, Joshi NS, Subbaraj L, Bronson RT, Xue W, Jacks T Nature. 2014 Oct 22. doi: 10.1038/nature13906.
KRAS and YAP1 Converge to Regulate EMT and Tumor Survival. Shao DD, Xue W, Krall EB, Bhutkar A, Piccioni F, Wang X, Schinzel AC, Sood S, Rosenbluh J, Kim JW, Zwang Y, Roberts TM, Root DE, Jacks T, Hahn WC Cell. 2014 Jul 3;158(1):171-84. doi: 10.1016/j.cell.2014.06.004. Epub 2014 Jun 19.
Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop. Oliver TG, Meylan E, Chang GP, Xue W, Burke JR, Humpton TJ, Hubbard D, Bhutkar A, Jacks T Mol Cell. 2011 Jul 8;43(1):57-71. doi: 10.1016/j.molcel.2011.06.012.
Suppression of lung adenocarcinoma progression by Nkx2-1. Winslow MM, Dayton TL, Verhaak RG, Kim-Kiselak C, Snyder EL, Feldser DM, Hubbard DD, DuPage MJ, Whittaker CA, Hoersch S, Yoon S, Crowley D, Bronson RT, Chiang DY, Meyerson M, Jacks T Nature. 2011 May 5. 473(7345):101-4.
Tissue-specific p19Arf regulation dictates the response to oncogenic K-ras. Young NP, Jacks T Proc Natl Acad Sci U S A. 2010 Jun 1. 107(22):10184-9.
Dicer1 functions as a haploinsufficient tumor suppressor. Kumar MS, Pester RE, Chen CY, Lane K, Chin C, Lu J, Kirsch DG, Golub TR, Jacks T Genes Dev. 2009 Nov 10. ():.
Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma. Meylan E, Dooley AL, Feldser DM, Shen L, Turk E, Ouyang C, Jacks T Nature. 2009 Nov 5;462(7269):104-7. doi: 10.1038/nature08462. Epub 2009 Oct 21.
Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Ventura A, Young AG, Winslow MM, Lintault L, Meissner A, Erkeland SJ, Newman J, Bronson RT, Crowley D, Stone JR, Jaenisch R, Sharp PA, Jacks T Cell. 2008 Mar 7. 132(5):875-86.
Suppression of non-small cell lung tumor development by the let-7 microRNA family. Kumar MS, Erkeland SJ, Pester RE, Chen CY, Ebert MS, Sharp PA, Jacks T Proc Natl Acad Sci U S A. 2008 Feb 28. ():.
Impaired microRNA processing enhances cellular transformation and tumorigenesis. Kumar MS, Lu J, Mercer KL, Golub TR, Jacks T Nat Genet. 2007 Apr 1. ():.
Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. Shaw AT, Meissner A, Dowdle JA, Crowley D, Magendantz M, Ouyang C, Parisi T, Rajagopal J, Blank LJ, Bronson RT, Stone JR, Tuveson DA, Jaenisch R, Jacks T Genes Dev. 2007 Mar 15. 21(6):694-707.
The Nf2 tumor suppressor regulates cell-cell adhesion during tissue fusion. McLaughlin ME, Kruger GM, Slocum KL, Crowley D, Michaud NA, Huang J, Magendantz M, Jacks T Proc Natl Acad Sci U S A. 2007 Feb 27. 104(9):3261-6.
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Olive KP, Tuveson DA, Ruhe ZC, Yin B, Willis NA, Bronson RT, Crowley D, Jacks T Cell. 2004 Dec 17. 119(6):847-60.
Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23. MacPherson D, Kim J, Kim T, Rhee BK, Van Oostrom CT, DiTullio RA, Venere M, Halazonetis TD, Bronson R, De Vries A, Fleming M, Jacks T EMBO J. 2004 Sep 15. 23(18):3689-99.
Cre-lox-regulated conditional RNA interference from transgenes. Ventura A, Meissner A, Dillon CP, McManus M, Sharp PA, Van Parijs L, Jaenisch R, Jacks T Proc Natl Acad Sci U S A. 2004 Jul 13. 101(28):10380-5.
Multiple response elements and differential p53 binding control Perp expression during apoptosis. Reczek EE, Flores ER, Tsay AS, Attardi LD, Jacks T Mol Cancer Res. 2003 Dec . 1(14):1048-57.
Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Sage J, Miller AL, Perez-Mancera PA, Wysocki JM, Jacks T Nature. 2003 Jul 10. 424(6945):223-8.
Cellular transformation by a FERM domain mutant of the Nf2 tumor suppressor gene. Johnson KC, Kissil JL, Fry JL, Jacks T Oncogene. 2002 Sep 5. 21(39):5990-7.
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Jackson EL, Willis N, Mercer K, Bronson RT, Crowley D, Montoya R, Jacks T, Tuveson DA Genes Dev. 2001 Dec 15. 15(24):3243-8.
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53. Boyd SD, Tsai KY, Jacks T Nat Cell Biol. 2000 Sep . 2(9):563-8.
Tumor spectrum analysis in p53-mutant mice. Jacks T, Remington L, Williams BO, Schmitt EM, Halachmi S, Bronson RT, Weinberg RA Curr Biol. 1994 Jan 1. 4(1):1-7.
Jacks Lab Unpublished Plasmids (unpublished)
Plasmid Gene/Insert Vector Type Publication Hidden Extra Search Info  
pSico Mammalian Expression, Lentiviral, RNAi, Cre/Lox Cre-lox-regulated conditional RNA interference from transgenes. Ventura et al Proc Natl Acad Sci U S A. 2004 Jul 13. 101(28):10380-5. pSico Add to Cart
pSicoR Mammalian Expression, Lentiviral, RNAi, Cre/Lox Cre-lox-regulated conditional RNA interference from transgenes. Ventura et al Proc Natl Acad Sci U S A. 2004 Jul 13. 101(28):10380-5. pSicoR Add to Cart
Lox-Stop-Lox TOPO loxP-STOP-loxP Mammalian Expression, Cre/Lox Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Jackson et al Genes Dev. 2001 Dec 15. 15(24):3243-8. pCR-Blunt II-TOPO Add to Cart
pSico PGK puro Mammalian Expression, Lentiviral, RNAi, Cre/Lox Cre-lox-regulated conditional RNA interference from transgenes. Ventura et al Proc Natl Acad Sci U S A. 2004 Jul 13. 101(28):10380-5. pSico PGK puro Add to Cart
pSicoR PGK puro Mammalian Expression, Lentiviral, RNAi, Cre/Lox Cre-lox-regulated conditional RNA interference from transgenes. Ventura et al Proc Natl Acad Sci U S A. 2004 Jul 13. 101(28):10380-5. pSicoR PGK puro Add to Cart
pCMV HDM2(C464A) HDM2 (Homo sapiens) Mammalian Expression An intact HDM2 RING-finger domain is required for nuclear exclusion of p53. Boyd et al Nat Cell Biol. 2000 Sep . 2(9):563-8. pCMV5 MDM2 ACTFS, HDMX, hdm2 Add to Cart
pCMV HDM2(NES-) HDM2 (Homo sapiens) Mammalian Expression An intact HDM2 RING-finger domain is required for nuclear exclusion of p53. Boyd et al Nat Cell Biol. 2000 Sep . 2(9):563-8. pCMV5 MDM2 ACTFS, HDMX, hdm2 Add to Cart
pSico p53 p53 shRNA (Mus musculus) Mammalian Expression, Lentiviral, RNAi, Cre/Lox Cre-lox-regulated conditional RNA interference from transgenes. Ventura et al Proc Natl Acad Sci U S A. 2004 Jul 13. 101(28):10380-5. pSico Trp53 RP23-56I20.1, Tp53, bbl, bfy, bhy, p44, p53 Add to Cart
pSicoR p53 p53 shRNA (Mus musculus) Mammalian Expression, Lentiviral, RNAi, Cre/Lox Cre-lox-regulated conditional RNA interference from transgenes. Ventura et al Proc Natl Acad Sci U S A. 2004 Jul 13. 101(28):10380-5. pSicoR Trp53 RP23-56I20.1, Tp53, bbl, bfy, bhy, p44, p53 Add to Cart
GFP-p53 p53 (Homo sapiens) Mammalian Expression An intact HDM2 RING-finger domain is required for nuclear exclusion of p53. Boyd et al Nat Cell Biol. 2000 Sep . 2(9):563-8. pEGFP-N1 TP53 BCC7, LFS1, P53, TRP53 Add to Cart
GFP-p53 (NES-) p53 (NES-) (Homo sapiens) Mammalian Expression An intact HDM2 RING-finger domain is required for nuclear exclusion of p53. Boyd et al Nat Cell Biol. 2000 Sep . 2(9):563-8. pEGFP-N1 TP53 BCC7, LFS1, P53, TRP53 Add to Cart
pSico PGK GFP Mammalian Expression, Lentiviral, RNAi, Cre/Lox Cre-lox-regulated conditional RNA interference from transgenes. Ventura et al Proc Natl Acad Sci U S A. 2004 Jul 13. 101(28):10380-5. pSico PGK GFP Add to Cart
pSico Dnmt1 Dnmt1 shRNA (Mus musculus) Mammalian Expression, Lentiviral, RNAi, Cre/Lox Cre-lox-regulated conditional RNA interference from transgenes. Ventura et al Proc Natl Acad Sci U S A. 2004 Jul 13. 101(28):10380-5. pSico Dnmt1 Cxxc9, Dnmt, Dnmt1o, MCMT, MTase, Met-1, Met1, MommeD2, m.MmuI Add to Cart
pSicoR Dnmt1 Dnmt1 shRNA (Mus musculus) Mammalian Expression, Lentiviral, RNAi, Cre/Lox Cre-lox-regulated conditional RNA interference from transgenes. Ventura et al Proc Natl Acad Sci U S A. 2004 Jul 13. 101(28):10380-5. pSicoR Dnmt1 Cxxc9, Dnmt, Dnmt1o, MCMT, MTase, Met-1, Met1, MommeD2, m.MmuI Add to Cart
p53 S23A targeting vector p53 (Mus musculus) Mammalian Expression, Cre/Lox Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23. MacPherson et al EMBO J. 2004 Sep 15. 23(18):3689-99. pBluescript II SK Trp53 RP23-56I20.1, Tp53, bbl, bfy, bhy, p44, p53 Add to Cart
pMB80 (R26-CreER) Rosa26 CreER^T2 Mammalian Expression, Cre/Lox The Nf2 tumor suppressor regulates cell-cell adhesion during tissue fusion. McLaughlin et al Proc Natl Acad Sci U S A. 2007 Feb 27. 104(9):3261-6. pROSA26-1 Add to Cart
pMB84 (Nf2 C-term) Nf2 C-terminal half (Mus musculus) Mammalian Expression, Cre/Lox The Nf2 tumor suppressor regulates cell-cell adhesion during tissue fusion. McLaughlin et al Proc Natl Acad Sci U S A. 2007 Feb 27. 104(9):3261-6. pCR-Blunt II-TOPO Nf2 RP23-280J3.6, merlin Add to Cart
MB121 (Nf2 BBA) Nf2 BBA (Mus musculus) Mammalian Expression Jacks Lab Unpublished Plasmids (unpublished) pIRES-hrGFP II Nf2 RP23-280J3.6, merlin Add to Cart
pSIRIP-puro shRNA p19-1 p19 ARF shRNA - 1 (Mus musculus) Mammalian Expression, Retroviral, RNAi Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Sage et al Nature. 2003 Jul 10. 424(6945):223-8. pSIRIP-puro Cdkn2a RP23-166I8.5, ARF-INK4a, Arf, INK4a-ARF, Ink4a/Arf, MTS1, Pctr1, p16, p16(INK4a), p16INK4a, p19<ARF>, p19ARF Add to Cart
pSIRIP-puro shRNA p19-2 p19 ARF shRNA -2 (Mus musculus) Mammalian Expression, Retroviral, RNAi Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Sage et al Nature. 2003 Jul 10. 424(6945):223-8. pSIRIP-puro Cdkn2a RP23-166I8.5, ARF-INK4a, Arf, INK4a-ARF, Ink4a/Arf, MTS1, Pctr1, p16, p16(INK4a), p16INK4a, p19<ARF>, p19ARF Add to Cart
pLenti-lox-GFP shRNA p19-2 p19 ARF shRNA -2 (Mus musculus) Mammalian Expression, Lentiviral, RNAi, Cre/Lox Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Sage et al Nature. 2003 Jul 10. 424(6945):223-8. pLL3.7 Cdkn2a RP23-166I8.5, ARF-INK4a, Arf, INK4a-ARF, Ink4a/Arf, MTS1, Pctr1, p16, p16(INK4a), p16INK4a, p19<ARF>, p19ARF Add to Cart
pBabe Nf2 wild-type Nf2 (Mus musculus) Mammalian Expression, Retroviral Cellular transformation by a FERM domain mutant of the Nf2 tumor suppressor gene. Johnson et al Oncogene. 2002 Sep 5. 21(39):5990-7. pBabe-puro Nf2 RP23-280J3.6, merlin Add to Cart
pBabe Nf2 delta BB Nf2 delta BB (Mus musculus) Mammalian Expression, Retroviral Cellular transformation by a FERM domain mutant of the Nf2 tumor suppressor gene. Johnson et al Oncogene. 2002 Sep 5. 21(39):5990-7. pBabe-puro Nf2 RP23-280J3.6, merlin Add to Cart
pSicoR human Dicer1 Dicer shRNA (Homo sapiens) Mammalian Expression, Lentiviral, RNAi, Cre/Lox Impaired microRNA processing enhances cellular transformation and tumorigenesis. Kumar et al Nat Genet. 2007 Apr 1. ():. pSicoR PGK puro DICER1 DCR1, Dicer, Dicer1e, HERNA, MNG1, RMSE2 Add to Cart
pSicoR human Dicer2 Dicer shRNA (Homo sapiens) Mammalian Expression, Lentiviral, RNAi, Cre/Lox Impaired microRNA processing enhances cellular transformation and tumorigenesis. Kumar et al Nat Genet. 2007 Apr 1. ():. pSicoR PGK puro DICER1 DCR1, Dicer, Dicer1e, HERNA, MNG1, RMSE2 Add to Cart
pSicoR human Dicer3 Dicer shRNA (Homo sapiens) Mammalian Expression, Lentiviral, RNAi, Cre/Lox Impaired microRNA processing enhances cellular transformation and tumorigenesis. Kumar et al Nat Genet. 2007 Apr 1. ():. pSicoR PGK puro DICER1 DCR1, Dicer, Dicer1e, HERNA, MNG1, RMSE2 Add to Cart
pSicoR human Drosha1 Drosha shRNA (Homo sapiens) Mammalian Expression, Lentiviral, RNAi, Cre/Lox Impaired microRNA processing enhances cellular transformation and tumorigenesis. Kumar et al Nat Genet. 2007 Apr 1. ():. pSicoR PGK puro DROSHA ETOHI2, HSA242976, RANSE3L, RN3, RNASE3L, RNASEN Add to Cart
pSicoR human Drosha2 Drosha shRNA (Homo sapiens) Mammalian Expression, Lentiviral, RNAi, Cre/Lox Impaired microRNA processing enhances cellular transformation and tumorigenesis. Kumar et al Nat Genet. 2007 Apr 1. ():. pSicoR PGK puro DROSHA ETOHI2, HSA242976, RANSE3L, RN3, RNASE3L, RNASEN Add to Cart
pSicoR human Drosha3 Drosha shRNA (Homo sapiens) Mammalian Expression, Lentiviral, RNAi, Cre/Lox Impaired microRNA processing enhances cellular transformation and tumorigenesis. Kumar et al Nat Genet. 2007 Apr 1. ():. pSicoR PGK puro DROSHA ETOHI2, HSA242976, RANSE3L, RN3, RNASE3L, RNASEN Add to Cart
pSicoR human DGCR8-1 DGCR8 shRNA (Homo sapiens) Mammalian Expression, Lentiviral, RNAi, Cre/Lox Impaired microRNA processing enhances cellular transformation and tumorigenesis. Kumar et al Nat Genet. 2007 Apr 1. ():. pSicoR PGK puro DGCR8 LP4941, C22orf12, DGCRK6, Gy1, pasha Add to Cart
pSicoR human DGCR8-2 DGCR8 shRNA (Homo sapiens) Mammalian Expression, Lentiviral, RNAi, Cre/Lox Impaired microRNA processing enhances cellular transformation and tumorigenesis. Kumar et al Nat Genet. 2007 Apr 1. ():. pSicoR PGK puro DGCR8 LP4941, C22orf12, DGCRK6, Gy1, pasha Add to Cart
pSicoR human DGCR8-3 DGCR8 shRNA (Homo sapiens) Mammalian Expression, Lentiviral, RNAi, Cre/Lox Impaired microRNA processing enhances cellular transformation and tumorigenesis. Kumar et al Nat Genet. 2007 Apr 1. ():. pSicoR PGK puro DGCR8 LP4941, C22orf12, DGCRK6, Gy1, pasha Add to Cart
pSuper mouse DGCR8-1 DGCR8 shRNA (Mus musculus) Mammalian Expression, Retroviral, RNAi Impaired microRNA processing enhances cellular transformation and tumorigenesis. Kumar et al Nat Genet. 2007 Apr 1. ():. pSUPER.retro.puro Dgcr8 D16H22S1742E, D16H22S788E, D16Wis2, Gy1, N41, Vo59c07 Add to Cart
pSuper mouse DGCR8-2 DGCR8 shRNA (Mus musculus) Mammalian Expression, Retroviral, RNAi Impaired microRNA processing enhances cellular transformation and tumorigenesis. Kumar et al Nat Genet. 2007 Apr 1. ():. pSUPER.retro.puro Dgcr8 D16H22S1742E, D16H22S788E, D16Wis2, Gy1, N41, Vo59c07 Add to Cart
pSuper mouse DGCR8-3 DGCR8 shRNA (Mus musculus) Mammalian Expression, Retroviral, RNAi Impaired microRNA processing enhances cellular transformation and tumorigenesis. Kumar et al Nat Genet. 2007 Apr 1. ():. pSUPER.retro.puro Dgcr8 D16H22S1742E, D16H22S788E, D16Wis2, Gy1, N41, Vo59c07 Add to Cart
pSuper mouse Drosha2 Drosha shRNA (Mus musculus) Mammalian Expression, Retroviral, RNAi Impaired microRNA processing enhances cellular transformation and tumorigenesis. Kumar et al Nat Genet. 2007 Apr 1. ():. pSUPER.retro.puro Drosha 1110013A17Rik, AI874853, Etohi2, Rn3, Rnasen Add to Cart
pSuper mouse Drosha3 Drosha shRNA (Mus musculus) Mammalian Expression, Retroviral, RNAi Impaired microRNA processing enhances cellular transformation and tumorigenesis. Kumar et al Nat Genet. 2007 Apr 1. ():. pSUPER.retro.puro Drosha 1110013A17Rik, AI874853, Etohi2, Rn3, Rnasen Add to Cart
pSuper mouse Dicer2 Dicer shRNA (Mus musculus) Mammalian Expression, Retroviral, RNAi Impaired microRNA processing enhances cellular transformation and tumorigenesis. Kumar et al Nat Genet. 2007 Apr 1. ():. pSUPER.retro.puro Dicer1 1110006F08Rik, D12Ertd7e, mKIAA0928 Add to Cart
pSuper mouse Dicer3 Dicer shRNA (Mus musculus) Mammalian Expression, Retroviral, RNAi Impaired microRNA processing enhances cellular transformation and tumorigenesis. Kumar et al Nat Genet. 2007 Apr 1. ():. pSUPER.retro.puro Dicer1 1110006F08Rik, D12Ertd7e, mKIAA0928 Add to Cart
pSuper mouse Dicer1 Dicer shRNA (Mus musculus) Mammalian Expression, Retroviral, RNAi Impaired microRNA processing enhances cellular transformation and tumorigenesis. Kumar et al Nat Genet. 2007 Apr 1. ():. pSUPER.retro.puro Dicer1 1110006F08Rik, D12Ertd7e, mKIAA0928 Add to Cart
pSuper mouse Drosha1 Drosha shRNA (Mus musculus) Mammalian Expression, Retroviral, RNAi Impaired microRNA processing enhances cellular transformation and tumorigenesis. Kumar et al Nat Genet. 2007 Apr 1. ():. pSUPER.retro.puro Drosha 1110013A17Rik, AI874853, Etohi2, Rn3, Rnasen Add to Cart
pSicoR mouse Dicer3 Dicer shRNA (Mus musculus) Mammalian Expression, Lentiviral, RNAi, Cre/Lox Impaired microRNA processing enhances cellular transformation and tumorigenesis. Kumar et al Nat Genet. 2007 Apr 1. ():. pSicoR PGK puro Dicer1 1110006F08Rik, D12Ertd7e, mKIAA0928 Add to Cart
pSicoR shluc Luciferase shRNA Mammalian Expression, Lentiviral, RNAi, Cre/Lox Impaired microRNA processing enhances cellular transformation and tumorigenesis. Kumar et al Nat Genet. 2007 Apr 1. ():. pSicoR PGK puro Add to Cart
MSCV let-7g let-7g (Mus musculus) Mammalian Expression, Retroviral Impaired microRNA processing enhances cellular transformation and tumorigenesis. Kumar et al Nat Genet. 2007 Apr 1. ():. MSCV-neo Add to Cart
pRL K-ras 3'UTR K-ras 3'UTR (Mus musculus) Mammalian Expression, Luciferase Impaired microRNA processing enhances cellular transformation and tumorigenesis. Kumar et al Nat Genet. 2007 Apr 1. ():. pRL-TK Kras RP24-359O2.1, AI929937, K-ras, Ki-ras, Kras-2, Kras2, p21B, ras Add to Cart
pRL K-ras 3'UTR mutant K-ras 3'UTR (Mus musculus) Mammalian Expression, Luciferase Impaired microRNA processing enhances cellular transformation and tumorigenesis. Kumar et al Nat Genet. 2007 Apr 1. ():. pRL-TK Kras RP24-359O2.1, AI929937, K-ras, Ki-ras, Kras-2, Kras2, p21B, ras Add to Cart
pRL c-Myc 3'UTR c-Myc 3'UTR (Mus musculus) Mammalian Expression, Luciferase Impaired microRNA processing enhances cellular transformation and tumorigenesis. Kumar et al Nat Genet. 2007 Apr 1. ():. pRL-TK Myc AU016757, Myc2, Niard, Nird, bHLHe39 Add to Cart
pSico Spry-2 Sprouty-2 shRNA (Mus musculus) Mammalian Expression, Lentiviral, RNAi, Cre/Lox Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. Shaw et al Genes Dev. 2007 Mar 15. 21(6):694-707. pSico Spry2 sprouty2 Add to Cart
pPERPluc1 PERP promoter (Mus musculus) Bacterial Expression, Luciferase Multiple response elements and differential p53 binding control Perp expression during apoptosis. Reczek et al Mol Cancer Res. 2003 Dec . 1(14):1048-57. pGL3-Basic Perp THW, KCP1, PIGPC1, KRTCAP1, 1110017A08Rik Add to Cart
pPERPlucFL PERP (Mus musculus) Bacterial Expression, Luciferase Multiple response elements and differential p53 binding control Perp expression during apoptosis. Reczek et al Mol Cancer Res. 2003 Dec . 1(14):1048-57. pGL3-Basic Perp THW, KCP1, PIGPC1, KRTCAP1, 1110017A08Rik Add to Cart
p53 KO neo p53KO (Mus musculus) Mammalian Expression Tumor spectrum analysis in p53-mutant mice. Jacks et al Curr Biol. 1994 Jan 1. 4(1):1-7. pPNT Trp53 RP23-56I20.1, Tp53, bbl, bfy, bhy, p44, p53 Add to Cart
Lox-stop-Lox p53 R270H p53 R270H (Mus musculus) Mammalian Expression, Cre/Lox Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Olive et al Cell. 2004 Dec 17. 119(6):847-60. pBluescript Trp53 RP23-56I20.1, Tp53, bbl, bfy, bhy, p44, p53 Add to Cart
Lox-stop-Lox p53 R172H p53 R172H (Mus musculus) Mammalian Expression, Cre/Lox Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Olive et al Cell. 2004 Dec 17. 119(6):847-60. pBluescript Trp53 RP23-56I20.1, Tp53, bbl, bfy, bhy, p44, p53 Add to Cart
Puro.Cre empty vector Mammalian Expression, Lentiviral, Cre/Lox Suppression of non-small cell lung tumor development by the let-7 microRNA family. Kumar et al Proc Natl Acad Sci U S A. 2008 Feb 28. ():. Puro.Cre Add to Cart
Puro.let-7g.Cre Let-7g (Mus musculus) Mammalian Expression, Lentiviral, Cre/Lox Suppression of non-small cell lung tumor development by the let-7 microRNA family. Kumar et al Proc Natl Acad Sci U S A. 2008 Feb 28. ():. Puro.Cre Add to Cart
Puro.let-7gsm.Cre Let-7g mutant (Mus musculus) Mammalian Expression, Lentiviral, Cre/Lox Suppression of non-small cell lung tumor development by the let-7 microRNA family. Kumar et al Proc Natl Acad Sci U S A. 2008 Feb 28. ():. Puro.Cre Add to Cart
pBabe zeo HMGA2 HMGA2 (Mus musculus) Mammalian Expression, Retroviral Suppression of non-small cell lung tumor development by the let-7 microRNA family. Kumar et al Proc Natl Acad Sci U S A. 2008 Feb 28. ():. pBabe-Zeo Hmga2 9430083A20Rik, HMGI-C, Hmgic, pg, pygmy Add to Cart
pBS-miR106a-363 microRNA 106a-363 (Mus musculus) Mouse Targeting Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Ventura et al Cell. 2008 Mar 7. 132(5):875-86. pBluescript KS(+) Mir106a Mirn106a Add to Cart
pKO-II-miR-17~92 microRNA 17-92 (Mus musculus) Mouse Targeting, Cre/Lox Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Ventura et al Cell. 2008 Mar 7. 132(5):875-86. pKOII Mir17 Mirn17, mmu-mir-17 Add to Cart
pKS-DTA miR-106b~25 microRNA 106a-25 (Mus musculus) Mouse Targeting Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Ventura et al Cell. 2008 Mar 7. 132(5):875-86. pKS-DTA Mir25 Mirn25, mmu-mir-25 Add to Cart
GFP.Cre empty vector Mammalian Expression, Lentiviral, Cre/Lox Jacks Lab Unpublished Plasmids (unpublished) GFP.Cre Add to Cart
Luc.Cre empty vector Mammalian Expression, Lentiviral, Cre/Lox Jacks Lab Unpublished Plasmids (unpublished) UbC.Luciferase.PGK.Cre Add to Cart
Ubc.IkBSR-Flag Pgk.Cre IkBSR (Mus musculus) Mammalian Expression, Lentiviral, Cre/Lox Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma. Meylan et al Nature. 2009 Nov 5;462(7269):104-7. doi: 10.1038/nature08462. Epub 2009 Oct 21. UbC.Luciferase.PGK.Cre Add to Cart
TRE.IkBSR-Flag Pgk.Cre IkBSR (Mus musculus) Mammalian Expression, Lentiviral, Cre/Lox Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma. Meylan et al Nature. 2009 Nov 5;462(7269):104-7. doi: 10.1038/nature08462. Epub 2009 Oct 21. pCW22TRE_PGKCre vector Add to Cart
pSicoR (Puro) NEMO shRNA1 NEMO shRNA1 (Mus musculus) Mammalian Expression, Lentiviral, RNAi, Cre/Lox Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma. Meylan et al Nature. 2009 Nov 5;462(7269):104-7. doi: 10.1038/nature08462. Epub 2009 Oct 21. pSicoR PGK puro Ikbkg RP23-15J3.1, 1110037D23Rik, AI848108, AI851264, AW124339, IKK[g], NEMO Add to Cart
pSicoR (Puro) NEMO shRNA2 NEMO shRNA2 (Mus musculus) Mammalian Expression, Lentiviral, RNAi, Cre/Lox Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma. Meylan et al Nature. 2009 Nov 5;462(7269):104-7. doi: 10.1038/nature08462. Epub 2009 Oct 21. pSicoR PGK puro Ikbkg RP23-15J3.1, 1110037D23Rik, AI848108, AI851264, AW124339, IKK[g], NEMO Add to Cart
pSicoR (Puro) p65 shRNA1 p65 shRNA1 (Mus musculus) Mammalian Expression, Lentiviral, RNAi, Cre/Lox Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma. Meylan et al Nature. 2009 Nov 5;462(7269):104-7. doi: 10.1038/nature08462. Epub 2009 Oct 21. pSicoR PGK puro Rela p65 Add to Cart
pSicoR (Puro) p65 shRNA2 p65 shRNA2 (Mus musculus) Mammalian Expression, Lentiviral, RNAi, Cre/Lox Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma. Meylan et al Nature. 2009 Nov 5;462(7269):104-7. doi: 10.1038/nature08462. Epub 2009 Oct 21. pSicoR PGK puro Rela p65 Add to Cart
pSicoR (GFP) cRel shRNA1 cRel shRNA1 (Mus musculus) Mammalian Expression, Lentiviral, RNAi, Cre/Lox Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma. Meylan et al Nature. 2009 Nov 5;462(7269):104-7. doi: 10.1038/nature08462. Epub 2009 Oct 21. pSicoR GFP Rel c-Rel Add to Cart
pSicoR (Puro) cRel shRNA2 cRel shRNA2 (Mus musculus) Mammalian Expression, Lentiviral, RNAi, Cre/Lox Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma. Meylan et al Nature. 2009 Nov 5;462(7269):104-7. doi: 10.1038/nature08462. Epub 2009 Oct 21. pSicoR PGK puro Rel c-Rel Add to Cart
Fret-Stop-Fret TOPO fret-STOP-fret Mammalian Expression Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Jackson et al Genes Dev. 2001 Dec 15. 15(24):3243-8. pCR-Blunt II-TOPO Add to Cart
MSCV CreERT2 puro CreERT2 Mammalian Expression, Retroviral Dicer1 functions as a haploinsufficient tumor suppressor. Kumar et al Genes Dev. 2009 Nov 10. ():. pMSCV puro Add to Cart
Lenti-LucOS OVA-SIY Mammalian Expression, Lentiviral, Cre/Lox Jacks Lab Unpublished Plasmids (unpublished) Luc.Cre (aka: UbC.Luciferase.PGK.Cre) Add to Cart
Lenti-LucS SIY Mammalian Expression, Lentiviral, Cre/Lox Jacks Lab Unpublished Plasmids (unpublished) Luc.Cre (aka: UbC.Luciferase.PGK.Cre) Add to Cart
pSICO-Flpo Flp recombinase Mammalian Expression, Lentiviral, RNAi, Cre/Lox Tissue-specific p19Arf regulation dictates the response to oncogenic K-ras. Young et al Proc Natl Acad Sci U S A. 2010 Jun 1. 107(22):10184-9. pSico Add to Cart
Puro 2.0 Mammalian Expression, Lentiviral, RNAi Tissue-specific p19Arf regulation dictates the response to oncogenic K-ras. Young et al Proc Natl Acad Sci U S A. 2010 Jun 1. 107(22):10184-9. Puro 2.0 Add to Cart
U6-shRNA pgkCre shRNA Mammalian Expression, Lentiviral, RNAi Tissue-specific p19Arf regulation dictates the response to oncogenic K-ras. Young et al Proc Natl Acad Sci U S A. 2010 Jun 1. 107(22):10184-9. unknown Add to Cart
MSCV-Nkx2-1/Puro Nkx2-1* (Mus musculus) Mammalian Expression, Retroviral Suppression of lung adenocarcinoma progression by Nkx2-1. Winslow et al Nature. 2011 May 5. 473(7345):101-4. MSCV-Puro Nkx2-1 AV026640, Nkx2.1, T/EBP, Titf1, Ttf-1 Add to Cart
MSCV-Nkx2-1*/Neo Nkx2-1* (Mus musculus) Mammalian Expression, Retroviral Suppression of lung adenocarcinoma progression by Nkx2-1. Winslow et al Nature. 2011 May 5. 473(7345):101-4. pMSCVNeo Nkx2-1 AV026640, Nkx2.1, T/EBP, Titf1, Ttf-1 Add to Cart
pLKO.shHmga2 shRNA targetting Hmga2 (Mus musculus) Mammalian Expression, Lentiviral, RNAi Suppression of lung adenocarcinoma progression by Nkx2-1. Winslow et al Nature. 2011 May 5. 473(7345):101-4. pLKO Hmga2 9430083A20Rik, HMGI-C, Hmgic, pg, pygmy Add to Cart
pLKO.shNkx2-1 shRNA targetting Nkx2-1 (Mus musculus) Mammalian Expression, Lentiviral, RNAi Suppression of lung adenocarcinoma progression by Nkx2-1. Winslow et al Nature. 2011 May 5. 473(7345):101-4. pLKO Nkx2-1 AV026640, Nkx2.1, T/EBP, Titf1, Ttf-1 Add to Cart
pCMV-myc3-Mdm2 D367E Mdm2 D367E (Homo sapiens) Mammalian Expression Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop. Oliver et al Mol Cell. 2011 Jul 8;43(1):57-71. doi: 10.1016/j.molcel.2011.06.012. expression of non-cleavable Mdm2 in mammalian cells pCMV MDM2 ACTFS, HDMX, hdm2 Add to Cart
pCMV-myc3-Mdm2 D367A Mdm2 D367A (Homo sapiens) Mammalian Expression Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop. Oliver et al Mol Cell. 2011 Jul 8;43(1):57-71. doi: 10.1016/j.molcel.2011.06.012. expression of non-cleavable Mdm2 in mammalian cells pCMV MDM2 ACTFS, HDMX, hdm2 Add to Cart
pCMV-myc3-Mdm2 p60 Mdm2 p60 (truncated) (Homo sapiens) Mammalian Expression Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop. Oliver et al Mol Cell. 2011 Jul 8;43(1):57-71. doi: 10.1016/j.molcel.2011.06.012. expression of truncated Mdm2 in mammalian cells pCMV MDM2 ACTFS, HDMX, hdm2 Add to Cart
MSCV-shCasp2-IRES-GFP Caspase-2 shRNA (Homo sapiens) Mammalian Expression, Retroviral Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop. Oliver et al Mol Cell. 2011 Jul 8;43(1):57-71. doi: 10.1016/j.molcel.2011.06.012. stable knockdown of Caspase-2 in mammalian cells MSCV-IRES-GFP-Puro CASP2 CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57 Add to Cart
TGMP.shKras.1422 Kras (Mus musculus) Retroviral KRAS and YAP1 Converge to Regulate EMT and Tumor Survival. Shao et al Cell. 2014 Jul 3;158(1):171-84. doi: 10.1016/j.cell.2014.06.004. Epub 2014 Jun 19. Tet on shKras for conditional Kras knockdown TGMP Kras RP24-359O2.1, AI929937, K-ras, Ki-ras, Kras-2, Kras2, p21B, ras Add to Cart
TRMPVneo.Yap.3093 Yap1 (Mus musculus) Retroviral KRAS and YAP1 Converge to Regulate EMT and Tumor Survival. Shao et al Cell. 2014 Jul 3;158(1):171-84. doi: 10.1016/j.cell.2014.06.004. Epub 2014 Jun 19. Tet on shRNA for conditional Yap1 knockdown TRMPVneo Yap1 AI325207, Yap, Yap65, Yki, Yorkie Add to Cart
pSECC Cas9 (Other), Cre Mammalian Expression, Mouse Targeting, Lentiviral, Cre/Lox, CRISPR Rapid modelling of cooperating genetic events in cancer through somatic genome editing. Sanchez-Rivera et al Nature. 2014 Oct 22. doi: 10.1038/nature13906. Expresses a sgRNA of interest, Cas9 and Cre pLL3.3 Add to Cart