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Xin Chen Lab Plasmids


The Xin Chen Lab has deposited plasmids at Addgene for distribution to the research community. Addgene is a non-profit plasmid repository dedicated to improving life science research.

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Title Authors Publication
Yes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma. Tschaharganeh DF, Chen X, Latzko P, Malz M, Gaida MM, Felix K, Ladu S, Singer S, Pinna F, Gretz N, Sticht C, Tomasi ML, Delogu S, Evert M, Fan B, Ribback S, Jiang L, Brozzetti S, Bergmann F, Dombrowski F, Schirmacher P, Calvisi DF, Breuhahn K Gastroenterology. 2013 Jun;144(7):1530-1542.e12. doi: 10.1053/j.gastro.2013.02.009. Epub 2013 Feb 16.
Cholangiocarcinomas can originate from hepatocytes in mice. Fan B, Malato Y, Calvisi DF, Naqvi S, Razumilava N, Ribback S, Gores GJ, Dombrowski F, Evert M, Chen X, Willenbring H J Clin Invest. 2012 Aug 1;122(8):2911-5. doi: 10.1172/JCI63212. Epub 2012 Jul 17.
Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma. Calvisi DF, Wang C, Ho C, Ladu S, Lee SA, Mattu S, Destefanis G, Delogu S, Zimmermann A, Ericsson J, Brozzetti S, Staniscia T, Chen X, Dombrowski F, Evert M Gastroenterology. 2011 Mar;140(3):1071-83. Epub 2010 Dec 11.
Bmi1 functions as an oncogene independent of Ink4A/Arf repression in hepatic carcinogenesis. Xu CR, Lee S, Ho C, Bommi P, Huang SA, Cheung ST, Dimri GP, Chen X Mol Cancer Res. 2009 Dec;7(12):1937-45. Epub 2009 Nov 24.
Distinct pathways of genomic progression to benign and malignant tumors of the liver. Tward AD, Jones KD, Yant S, Cheung ST, Fan ST, Chen X, Kay MA, Wang R, Bishop JM Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14771-6. Epub 2007 Sep 4.
Plasmid Gene/Insert Vector Type Publication Hidden Extra Search Info  
pT3-EF1a-Bmi1 Bmi1 (Homo sapiens) Mammalian Expression Bmi1 functions as an oncogene independent of Ink4A/Arf repression in hepatic carcinogenesis. Xu et al Mol Cancer Res. 2009 Dec;7(12):1937-45. Epub 2009 Nov 24. pT3-EF1a BMI1 RP11-573G6.1, FLVI2/BMI1, PCGF4, RNF51 Add to Cart
pT3-EF1a-c-Met Met (Homo sapiens) Mammalian Expression Distinct pathways of genomic progression to benign and malignant tumors of the liver. Tward et al Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14771-6. Epub 2007 Sep 4. pT3-EF1a MET AUTS9, HGFR, RCCP2, c-Met Add to Cart
pT3-N90-beta-catenin beta-catenin (Homo sapiens) Mammalian Expression Distinct pathways of genomic progression to benign and malignant tumors of the liver. Tward et al Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14771-6. Epub 2007 Sep 4. pT3-EF1a CTNNB1 OK/SW-cl.35, CTNNB, MRD19, armadillo Add to Cart
pENTR-c-Met Met (Homo sapiens) Entry Vector Distinct pathways of genomic progression to benign and malignant tumors of the liver. Tward et al Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14771-6. Epub 2007 Sep 4. pENTR1A MET AUTS9, HGFR, RCCP2, c-Met Add to Cart
pENTR-N90-beta-catenin beta-catenin (Homo sapiens) Entry Vector Distinct pathways of genomic progression to benign and malignant tumors of the liver. Tward et al Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14771-6. Epub 2007 Sep 4. pENTR1A
  • Tag / Fusion Protein
    • Myc (N terminal on insert)
  • CTNNB1 OK/SW-cl.35, CTNNB, MRD19, armadillo
    Add to Cart
    pT3-myr-AKT-HA AKT1 (Homo sapiens) Mammalian Expression Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma. Calvisi et al Gastroenterology. 2011 Mar;140(3):1071-83. Epub 2010 Dec 11. pT3-EF1a AKT1 AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA Add to Cart
    pENTR-myr-AKT-HA AKT1 (Homo sapiens) Entry Vector Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma. Calvisi et al Gastroenterology. 2011 Mar;140(3):1071-83. Epub 2010 Dec 11. pENTR1A AKT1 AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA Add to Cart
    pT3-EF1a-NICD1 Notch1 (C-term) (Mus musculus) Mammalian Expression Cholangiocarcinomas can originate from hepatocytes in mice. Fan et al J Clin Invest. 2012 Aug 1;122(8):2911-5. doi: 10.1172/JCI63212. Epub 2012 Jul 17. pT3-EF1a Notch1 RP23-306D20.12-001, 9930111A19Rik, Mis6, N1, Tan1, lin-12 Add to Cart
    pENTR-NICD1 Notch1 (C-term) (Mus musculus) Entry Vector Cholangiocarcinomas can originate from hepatocytes in mice. Fan et al J Clin Invest. 2012 Aug 1;122(8):2911-5. doi: 10.1172/JCI63212. Epub 2012 Jul 17. pENTR Notch1 RP23-306D20.12-001, 9930111A19Rik, Mis6, N1, Tan1, lin-12 Add to Cart
    pT-3EF1a-Yap S127A Yes-kinase associated protein (Homo sapiens) Mammalian Expression Yes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma. Tschaharganeh et al Gastroenterology. 2013 Jun;144(7):1530-1542.e12. doi: 10.1053/j.gastro.2013.02.009. Epub 2013 Feb 16. pT3-EF1a YAP1 COB1, YAP, YAP2, YAP65, YKI Add to Cart
    pENTR1A-Yap S127A Yes-kinase associated protein (Homo sapiens) Entry Vector Yes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma. Tschaharganeh et al Gastroenterology. 2013 Jun;144(7):1530-1542.e12. doi: 10.1053/j.gastro.2013.02.009. Epub 2013 Feb 16. pENTR YAP1 COB1, YAP, YAP2, YAP65, YKI Add to Cart
    pT-3EF1a-HA-Jag1 Jag1 (Rattus norvegicus) Mammalian Expression Yes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma. Tschaharganeh et al Gastroenterology. 2013 Jun;144(7):1530-1542.e12. doi: 10.1053/j.gastro.2013.02.009. Epub 2013 Feb 16. pT3-EF1a Jag1 Add to Cart
    pENTR1A-HA-Jag1 Jag1 (Rattus norvegicus) Entry Vector Yes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma. Tschaharganeh et al Gastroenterology. 2013 Jun;144(7):1530-1542.e12. doi: 10.1053/j.gastro.2013.02.009. Epub 2013 Feb 16. pENTR Jag1 Add to Cart