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Xin Chen Lab Plasmids


The Xin Chen Lab has deposited plasmids at Addgene for distribution to the research community. Addgene is a nonprofit plasmid repository dedicated to improving life science research.

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Title Authors Publication
Distinct pathways of genomic progression to benign and malignant tumors of the liver. Tward AD, Jones KD, Yant S, Cheung ST, Fan ST, Chen X, Kay MA, Wang R, Bishop JM Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14771-6. Epub 2007 Sep 4.
Bmi1 functions as an oncogene independent of Ink4A/Arf repression in hepatic carcinogenesis. Xu CR, Lee S, Ho C, Bommi P, Huang SA, Cheung ST, Dimri GP, Chen X Mol Cancer Res. 2009 Dec;7(12):1937-45. Epub 2009 Nov 24.
Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma. Calvisi DF, Wang C, Ho C, Ladu S, Lee SA, Mattu S, Destefanis G, Delogu S, Zimmermann A, Ericsson J, Brozzetti S, Staniscia T, Chen X, Dombrowski F, Evert M Gastroenterology. 2011 Mar;140(3):1071-83. Epub 2010 Dec 11.
Cholangiocarcinomas can originate from hepatocytes in mice. Fan B, Malato Y, Calvisi DF, Naqvi S, Razumilava N, Ribback S, Gores GJ, Dombrowski F, Evert M, Chen X, Willenbring H J Clin Invest. 2012 Aug 1;122(8):2911-5. doi: 10.1172/JCI63212. Epub 2012 Jul 17.
Yes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma. Tschaharganeh DF, Chen X, Latzko P, Malz M, Gaida MM, Felix K, Ladu S, Singer S, Pinna F, Gretz N, Sticht C, Tomasi ML, Delogu S, Evert M, Fan B, Ribback S, Jiang L, Brozzetti S, Bergmann F, Dombrowski F, Schirmacher P, Calvisi DF, Breuhahn K Gastroenterology. 2013 Jun;144(7):1530-1542.e12. doi: 10.1053/j.gastro.2013.02.009. Epub 2013 Feb 16.
A functional mTORC1 signaling is indispensable for c-Myc driven hepatocarcinogenesis. Liu P, Ge M, Hu J, Li X, Che L, Sun K, Cheng L, Huang Y, Pilo MG, Cigliano A, Pes GM, Pascale RM, Brozzetti S, Vidili G, Porcu A, Cossu A, Palmieri G, Sini MC, Ribback S, Dombrowski F, Tao J, Calvisi DF, Chen L, Chen X Hepatology. 2017 Mar 30. doi: 10.1002/hep.29183.
ID Plasmid Gene/Insert Vector Type Publication Hidden Extra Search Info  
31783pT3-EF1a-Bmi1Bmi1 (Homo sapiens)Mammalian ExpressionBmi1 functions as an oncogene independent of Ink4A/Arf repression in hepatic carcinogenesis. Mol Cancer Res. 2009 Dec;7(12):1937-45. Epub 2009 Nov 24. pT3-EF1a BMI1 FLVI2/BMI1, PCGF4, RNF51, flvi-2/bmi-1 Add to Cart
31784pT3-EF1a-c-MetMet (Homo sapiens)Mammalian ExpressionDistinct pathways of genomic progression to benign and malignant tumors of the liver. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14771-6. Epub 2007 Sep 4. pT3-EF1a MET AUTS9, DFNB97, HGFR, RCCP2, c-Met Add to Cart
31785pT3-N90-beta-cateninbeta-catenin (Homo sapiens)Mammalian ExpressionDistinct pathways of genomic progression to benign and malignant tumors of the liver. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14771-6. Epub 2007 Sep 4. pT3-EF1a CTNNB1 CTNNB, MRD19, armadillo Add to Cart
31786pENTR-c-MetMet (Homo sapiens)Entry VectorDistinct pathways of genomic progression to benign and malignant tumors of the liver. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14771-6. Epub 2007 Sep 4. pENTR1A MET AUTS9, DFNB97, HGFR, RCCP2, c-Met Add to Cart
31787pENTR-N90-beta-cateninbeta-catenin (Homo sapiens)Entry VectorDistinct pathways of genomic progression to benign and malignant tumors of the liver. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14771-6. Epub 2007 Sep 4. pENTR1A
  • Tag / Fusion Protein
    • Myc (N terminal on insert)
  • CTNNB1 CTNNB, MRD19, armadillo
    Add to Cart
    31789pT3-myr-AKT-HAAKT1 (Homo sapiens)Mammalian ExpressionIncreased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma. Gastroenterology. 2011 Mar;140(3):1071-83. Epub 2010 Dec 11. pT3-EF1a AKT1 AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA Add to Cart
    31790pENTR-myr-AKT-HAAKT1 (Homo sapiens)Entry VectorIncreased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma. Gastroenterology. 2011 Mar;140(3):1071-83. Epub 2010 Dec 11. pENTR1A AKT1 AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA Add to Cart
    46047pT3-EF1a-NICD1Notch1 (C-term) (Mus musculus)Mammalian ExpressionCholangiocarcinomas can originate from hepatocytes in mice. J Clin Invest. 2012 Aug 1;122(8):2911-5. doi: 10.1172/JCI63212. Epub 2012 Jul 17. pT3-EF1a Notch1 9930111A19Rik, Mis6, N1, Tan1, lin-12 Add to Cart
    46048pENTR-NICD1Notch1 (C-term) (Mus musculus)Entry Vector Cholangiocarcinomas can originate from hepatocytes in mice. J Clin Invest. 2012 Aug 1;122(8):2911-5. doi: 10.1172/JCI63212. Epub 2012 Jul 17. pENTR Notch1 9930111A19Rik, Mis6, N1, Tan1, lin-12 Add to Cart
    46049pT-3EF1a-Yap S127AYes-kinase associated protein (Homo sapiens)Mammalian ExpressionYes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma. Gastroenterology. 2013 Jun;144(7):1530-1542.e12. doi: 10.1053/j.gastro.2013.02.009. Epub 2013 Feb 16. pT3-EF1a YAP1 COB1, YAP, YAP2, YAP65, YKI Add to Cart
    46050pENTR1A-Yap S127AYes-kinase associated protein (Homo sapiens)Entry VectorYes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma. Gastroenterology. 2013 Jun;144(7):1530-1542.e12. doi: 10.1053/j.gastro.2013.02.009. Epub 2013 Feb 16. pENTR YAP1 COB1, YAP, YAP2, YAP65, YKI Add to Cart
    46051pT-3EF1a-HA-Jag1Jag1 (Rattus norvegicus)Mammalian ExpressionYes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma. Gastroenterology. 2013 Jun;144(7):1530-1542.e12. doi: 10.1053/j.gastro.2013.02.009. Epub 2013 Feb 16. pT3-EF1a Jag1 Add to Cart
    46052pENTR1A-HA-Jag1Jag1 (Rattus norvegicus)Entry VectorYes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma. Gastroenterology. 2013 Jun;144(7):1530-1542.e12. doi: 10.1053/j.gastro.2013.02.009. Epub 2013 Feb 16. pENTR Jag1 Add to Cart
    86497pT3-EF1aH Yap S127AYes associated protein 1 (Homo sapiens)Mammalian ExpressionYes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma. Gastroenterology. 2013 Jun;144(7):1530-1542.e12. doi: 10.1053/j.gastro.2013.02.009. Epub 2013 Feb 16. Mammalian expression of FLAG-tagged Yap containing S127A mutation pT3-EF1aH YAP1 COB1, YAP, YAP2, YAP65, YKI Add to Cart
    86498pT3-EF1aH c-MetMet (Homo sapiens)Mammalian ExpressionDistinct pathways of genomic progression to benign and malignant tumors of the liver. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14771-6. Epub 2007 Sep 4. Mammalian expression of HA tagged c-Met pT3-EF1aH MET AUTS9, DFNB97, HGFR, RCCP2, c-Met Add to Cart
    86499pT3-EF1aH N90-beta-cateninbeta-catenin (Homo sapiens)Mammalian ExpressionDistinct pathways of genomic progression to benign and malignant tumors of the liver. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14771-6. Epub 2007 Sep 4. Mammalian expression of Myc tagged N90 beta-catenin pT3-EF1aH CTNNB1 CTNNB, MRD19, armadillo Add to Cart
    86500pT3-EF1aH NICD1Notch1 (C-term) (Mus musculus)Mammalian ExpressionCholangiocarcinomas can originate from hepatocytes in mice. J Clin Invest. 2012 Aug 1;122(8):2911-5. doi: 10.1172/JCI63212. Epub 2012 Jul 17. Mammalian expression of Myc tagged NICD1 pT3-EF1aH Notch1 9930111A19Rik, Mis6, N1, Tan1, lin-12 Add to Cart
    92046c-myc-PT3EF1aC-MYC (Homo sapiens)Mammalian ExpressionA functional mTORC1 signaling is indispensable for c-Myc driven hepatocarcinogenesis. Hepatology. 2017 Mar 30. doi: 10.1002/hep.29183. Expresses c-Myc in mammalian cells pT3-EF1a MYC MRTL, MYCC, bHLHe39, c-Myc Add to Cart