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WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
Chan EM, Shibue T, McFarland JM, Gaeta B, Ghandi M, Dumont N, Gonzalez A, McPartlan JS, Li T, Zhang Y, Bin Liu J, Lazaro JB, Gu P, Piett CG, Apffel A, Ali SO, Deasy R, Keskula P, Ng RWS, Roberts EA, Reznichenko E, Leung L, Alimova M, Schenone M, Islam M, Maruvka YE, Liu Y, Roper J, Raghavan S, Giannakis M, Tseng YY, Nagel ZD, D'Andrea A, Root DE, Boehm JS, Getz G, Chang S, Golub TR, Tsherniak A, Vazquez F, Bass AJ
Nature. 2019 Apr 10. pii: 10.1038/s41586-019-1102-x. doi: 10.1038/s41586-019-1102-x.
PubMed Article

Plasmids from Article

ID Plasmid  
125767pXPR_BRD003-sgCh2-2
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125768pXPR_BRD003-sgCh2-4
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125769pXPR_BRD003-sgPOLR2D
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125770pXPR_BRD003-sgMYC
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125771pXPR_BRD003-sgWRN1
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125772pXPR_BRD003-sgWRN2
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125773pXPR_BRD003-sgWRN3
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125774pXPR_BRD003-sgWRN-EIJ
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125775pXPR_BRD051-sgCh2-2
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125776pXPR_BRD051-sgMLH1-1
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125777pXPR_BRD051-sgMLH1-2
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125778pLKO.1-puro-shRFP
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125779pLKO.1-puro-shPSMD2
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125780pLKO.1-puro-shRPS6
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125781pLKO.1-puro-shWRN1
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125782pLKO.1-puro-shWRN2
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125783pRSITEP-puro-shWRN1
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125784pRSITEP-puro-shWRN1-C911
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125785pRSITEP-puro-shWRN2
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125786pRSITEP-puro-shWRN2-C911
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125788pLX209-neo-active WRN
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125789pLX209-neo-WRN E84A
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125790pLX209-neo-WRN K577M
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125791pLX209-neo-WRN E84A K577M
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