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D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction.
Gobeil SM, Janowska K, McDowell S, Mansouri K, Parks R, Manne K, Stalls V, Kopp MF, Henderson R, Edwards RJ, Haynes BF, Acharya P
Cell Rep. 2021 Jan 12;34(2):108630. doi: 10.1016/j.celrep.2020.108630. Epub 2020 Dec 26.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
164565pαH-S-GSASSARS-CoV-2 Spike protein (S-GSAS variant)
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164566pαH-S-GSAS/D614GSARS-CoV-2 Spike protein with D614G mutation (S-GSAS-D614G variant)
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164567pαH-S-HRV3CSARS-CoV-2 Spike protein with furin site mutated to HRV3C site (S-HRV3C variant)
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164568pαH-S-HRV3C/D614GSARS-CoV-2 Spike protein with furin site mutated to HRV3C site and D614G mutation (S-HRV3C-D614G variant)
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164569pαH-S-RRARSARS-CoV-2 Spike protein with Furin site restored (S-RRAR variant)
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164570pαH-S-RRAR/D614GSARS-CoV-2 Spike protein with D614G mutation and Furin site restored (S-RRAR-D614G variant)
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