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Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals.
Qiu J, Tan YW, Hagenston AM, Martel MA, Kneisel N, Skehel PA, Wyllie DJ, Bading H, Hardingham GE
Nat Commun. 2013;4:2034. doi: 10.1038/ncomms3034.
PubMed Article

Plasmids from Article

ID Plasmid Purpose
181865pAAV-MCU-tDimerExpresses tDimer-tagged mitochondrial calcium uniporter (MCU) under control of the CaMKIIa promoter
181866pAAV-MCU-EGFPExpresses GFP-tagged mitochondrial calcium uniporter (MCU) under control of the CaMKIIa promoter
181867pAAV-shMcu-2Expresses Mcu-targeted shRNA under control of the U6 promoter and hrGFP under control of the synthetic CAG promoter
181868pAAV-shMcu-1Expresses Mcu-targeted shRNA under control of the U6 promoter and hrGFP under control of the synthetic CAG promoter

Antibodies from Article