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Mini-PCDH15 gene therapy rescues hearing in a mouse model of Usher syndrome type 1F.
Ivanchenko MV, Hathaway DM, Klein AJ, Pan B, Strelkova O, De-la-Torre P, Wu X, Peters CW, Mulhall EM, Booth KT, Goldstein C, Brower J, Sotomayor M, Indzhykulian AA, Corey DP
Nat Commun. 2023 Apr 26;14(1):2400. doi: 10.1038/s41467-023-38038-y. PubMed Article

Plasmids from Article

ID Plasmid Purpose
199184pAAV_-CMV-Pcdh15_mini_V4-CD2An AAV plasmid designed to facilitate the expression of mini-PCDH15 in the inner ear of a mouse.
199185pAAV-CMV-N-HA-Pcdh15_mini_V4An AAV plasmid designed to facilitate the expression of mini-PCDH15 in the inner ear of a mouse.
199186pAAV-CMV-Pcdh15_mini_V7-CD2An AAV plasmid designed to facilitate the expression of mini-PCDH15 in the inner ear of a mouse.
199187pAAV-CMV-Pcdh15_mini_V8-CD2An AAV plasmid designed to facilitate the expression of mini-PCDH15 in the inner ear of a mouse.

Antibodies from Article