Advancing Biology with Zebrafish: Genetic Tools for Developmental Studies and More
Type
Blog Post
Published
Aug. 13, 2019, 12:58 p.m.
... are not ideal for every application. Disadvantages include their duplicated (i.e., redundant) genome,...mutant, which regulates a developmental pathway implicated in congenital heart defects and cancer. These...its translation either by blocking initiation or splicing. (RNAi, in contrast, engages existing gene regulatory...DNA into the genome is useful for a variety of applications. For example, specific tissues such as blood...pathways control this process.
Additional zebrafish applications and conclusions
Zebrafish are also popular outside...—have proven useful in a variety of research applications. Lineage tracing studies highlight how these...Contemporary zebrafish transgenesis with Tol2 and application for Cre/lox recombination experiments." Methods...