Skip to main content
This website uses cookies to ensure you get the best experience. By continuing to use this site, you agree to the use of cookies.

Please note: Your browser does not support the features used on Addgene's website. You may not be able to create an account or request plasmids through this website until you upgrade your browser. Learn more

Please note: Your browser does not fully support some of the features used on Addgene's website. If you run into any problems registering, depositing, or ordering please contact us at [email protected] Learn more

pCDNA3-Flag MKK6 Citations (6)

Plasmid Article: MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.
Raingeaud J, Whitmarsh AJ, Barrett T, Derijard B, Davis RJ Mol Cell Biol. 1996 Mar . 16(3):1247-55.

Articles Citing pCDNA3-Flag MKK6

MKK4/SEK1 is negatively regulated through a feedback loop involving the E3 ubiquitin ligase itch. Ahn YH, Kurie JM. J Biol Chem. 2009 Oct 23;284(43):29399-404. doi: 10.1074/jbc.M109.044958. Epub 2009 Sep 8. PubMed
F-box only protein 31 (FBXO31) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6). Liu J, Han L, Li B, Yang J, Huen MS, Pan X, Tsao SW, Cheung AL. J Biol Chem. 2014 Aug 1;289(31):21508-18. doi: 10.1074/jbc.M114.560342. Epub 2014 Jun 16. PubMed
Hepatic mitogen-activated protein kinase phosphatase 1 selectively regulates glucose metabolism and energy homeostasis. Lawan A, Zhang L, Gatzke F, Min K, Jurczak MJ, Al-Mutairi M, Richter P, Camporez JP, Couvillon A, Pesta D, Roth Flach RJ, Shulman GI, Bennett AM. Mol Cell Biol. 2015 Jan;35(1):26-40. doi: 10.1128/MCB.00503-14. Epub 2014 Oct 13. PubMed
Specificity of Phosphorylation Responses to Mitogen Activated Protein (MAP) Kinase Pathway Inhibitors in Melanoma Cells. Basken J, Stuart SA, Kavran AJ, Lee T, Ebmeier CC, Old WM, Ahn NG. Mol Cell Proteomics. 2018 Apr;17(4):550-564. doi: 10.1074/mcp.RA117.000335. Epub 2017 Dec 18. PubMed
Phenotype-based screens with conformation-specific inhibitors reveal p38 gamma and delta as targets for HCC polypharmacology. Yu JX, Craig AJ, Duffy ME, Villacorta-Martin C, Miguela V, Ruiz de Galarreta M, Scopton AP, Silber L, Maldonado AY, Rialdi A, Guccione E, Lujambio A, Villanueva A, Dar AC. Mol Cancer Ther. 2019 Jun 18. pii: 1535-7163.MCT-18-0571. doi: 10.1158/1535-7163.MCT-18-0571. PubMed
Optical control of MAP kinase kinase 6 (MKK6) reveals that it has divergent roles in pro-apoptotic and anti-proliferative signaling. Rahman SMT, Zhou W, Deiters A, Haugh JM. J Biol Chem. 2020 Jun 19;295(25):8494-8504. doi: 10.1074/jbc.RA119.012079. Epub 2020 May 5. PubMed

If you have published an article using this plasmid, please email us at [email protected] to have your article added to this page.