MEK1-GFP Citations (15)

Originally described in: Non-regulated and stimulated mechanisms cooperate in the nuclear accumulation of MEK1.
Yao Z, Flash I, Raviv Z, Yung Y, Asscher Y, Pleban S, Seger R Oncogene. 2001 Nov 15. 20(52):7588-96. PubMed Journal

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Articles Citing MEK1-GFP

Articles
MAT2B-GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer. Peng H, Dara L, Li TW, Zheng Y, Yang H, Tomasi ML, Tomasi I, Giordano P, Mato JM, Lu SC. Hepatology. 2013 Jun;57(6):2299-313. doi: 10.1002/hep.26258. Epub 2013 May 14. PubMed
Comparative sequencing analysis reveals high genomic concordance between matched primary and metastatic colorectal cancer lesions. Brannon AR, Vakiani E, Sylvester BE, Scott SN, McDermott G, Shah RH, Kania K, Viale A, Oschwald DM, Vacic V, Emde AK, Cercek A, Yaeger R, Kemeny NE, Saltz LB, Shia J, D'Angelica MI, Weiser MR, Solit DB, Berger MF. Genome Biol. 2014 Aug 28;15(8):454. doi: 10.1186/s13059-014-0454-7. PubMed
Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis. Chakraborty R, Hampton OA, Shen X, Simko SJ, Shih A, Abhyankar H, Lim KP, Covington KR, Trevino L, Dewal N, Muzny DM, Doddapaneni H, Hu J, Wang L, Lupo PJ, Hicks MJ, Bonilla DL, Dwyer KC, Berres ML, Poulikakos PI, Merad M, McClain KL, Wheeler DA, Allen CE, Parsons DW. Blood. 2014 Nov 6;124(19):3007-15. doi: 10.1182/blood-2014-05-577825. Epub 2014 Sep 8. PubMed
MAP2K1 (MEK1) Mutations Define a Distinct Subset of Lung Adenocarcinoma Associated with Smoking. Arcila ME, Drilon A, Sylvester BE, Lovly CM, Borsu L, Reva B, Kris MG, Solit DB, Ladanyi M. Clin Cancer Res. 2015 Apr 15;21(8):1935-43. doi: 10.1158/1078-0432.CCR-14-2124. Epub 2014 Oct 28. PubMed
Methionine adenosyltransferase 2B-GIT1 complex serves as a scaffold to regulate Ras/Raf/MEK1/2 activity in human liver and colon cancer cells. Peng H, Li TW, Yang H, Moyer MP, Mato JM, Lu SC. Am J Pathol. 2015 Apr;185(4):1135-44. doi: 10.1016/j.ajpath.2014.12.016. PubMed
Extreme Outlier Analysis Identifies Occult Mitogen-Activated Protein Kinase Pathway Mutations in Patients With Low-Grade Serous Ovarian Cancer. Grisham RN, Sylvester BE, Won H, McDermott G, DeLair D, Ramirez R, Yao Z, Shen R, Dao F, Bogomolniy F, Makker V, Sala E, Soumerai TE, Hyman DM, Socci ND, Viale A, Gershenson DM, Farley J, Levine DA, Rosen N, Berger MF, Spriggs DR, Aghajanian CA, Solit DB, Iyer G. J Clin Oncol. 2015 Dec 1;33(34):4099-105. doi: 10.1200/JCO.2015.62.4726. Epub 2015 Aug 31. PubMed
Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling. Dhawan NS, Scopton AP, Dar AC. Nature. 2016 Sep 1;537(7618):112-116. doi: 10.1038/nature19327. Epub 2016 Aug 24. PubMed
3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets. Gao J, Chang MT, Johnsen HC, Gao SP, Sylvester BE, Sumer SO, Zhang H, Solit DB, Taylor BS, Schultz N, Sander C. Genome Med. 2017 Jan 23;9(1):4. doi: 10.1186/s13073-016-0393-x. PubMed
Heat Shock-induced Phosphorylation of TAR DNA-binding Protein 43 (TDP-43) by MAPK/ERK Kinase Regulates TDP-43 Function. Li W, Reeb AN, Lin B, Subramanian P, Fey EE, Knoverek CR, French RL, Bigio EH, Ayala YM. J Biol Chem. 2017 Mar 24;292(12):5089-5100. doi: 10.1074/jbc.M116.753913. Epub 2017 Feb 6. PubMed
LINE-1 protein localization and functional dynamics during the cell cycle. Mita P, Wudzinska A, Sun X, Andrade J, Nayak S, Kahler DJ, Badri S, LaCava J, Ueberheide B, Yun CY, Fenyo D, Boeke JD. Elife. 2018 Jan 8;7. pii: 30058. doi: 10.7554/eLife.30058. PubMed
Clinical resistance associated with a novel MAP2K1 mutation in a patient with Langerhans cell histiocytosis. Azorsa DO, Lee DW, Wai DH, Bista R, Patel AR, Aleem E, Henry MM, Arceci RJ. Pediatr Blood Cancer. 2018 Sep;65(9):e27237. doi: 10.1002/pbc.27237. Epub 2018 May 16. PubMed
Widespread Selection for Oncogenic Mutant Allele Imbalance in Cancer. Bielski CM, Donoghue MTA, Gadiya M, Hanrahan AJ, Won HH, Chang MT, Jonsson P, Penson AV, Gorelick A, Harris C, Schram AM, Syed A, Zehir A, Chapman PB, Hyman DM, Solit DB, Shannon K, Chandarlapaty S, Berger MF, Taylor BS. Cancer Cell. 2018 Nov 12;34(5):852-862.e4. doi: 10.1016/j.ccell.2018.10.003. Epub 2018 Nov 1. PubMed
Leveraging systematic functional analysis to benchmark an in silico framework distinguishes driver from passenger MEK mutants in cancer. Hanrahan AJ, Sylvester BE, Chang MT, Elzein A, Gao J, Han W, Liu Y, Xu D, Gao SP, Gorelick AN, Jones AM, Kiliti AJ, Nissan MH, Nimura CA, Poteshman AN, Yao Z, Gao Y, Hu W, Wise HC, Gavrila EI, Shoushtari AN, Tiwari S, Viale A, Abdel-Wahab O, Merghoub T, Berger MF, Rosen N, Taylor BS, Solit DB. Cancer Res. 2020 Jul 8. pii: 0008-5472.CAN-20-0865. doi: 10.1158/0008-5472.CAN-20-0865. PubMed
MEK1 drives oncogenic signaling and interacts with PARP1 for genomic and metabolic homeostasis in malignant pleural mesothelioma. Yang H, Gao Y, Xu D, Xu K, Liang SQ, Yang Z, Scherz A, Hall SRR, Forster S, Berezowska S, Yao F, Ochsenbein AF, Marti TM, Kocher GJ, Schmid RA, Dorn P, Peng RW. Cell Death Discov. 2023 Feb 10;9(1):55. doi: 10.1038/s41420-023-01307-2. PubMed
Aged black garlic extract inhibits the growth of estrogen receptor-positive breast cancer cells by downregulating MCL-1 expression through the ROS-JNK pathway. Yang Q, Li F, Jia G, Liu R. PLoS One. 2023 Jun 23;18(6):e0286454. doi: 10.1371/journal.pone.0286454. eCollection 2023. PubMed

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