Klotho (membrane) Citations (14)
Originally described in: Association of human aging with a functional variant of klotho.Arking DE, Krebsova A, Macek M, Macek M, Arking A, Mian IS, Fried L, Hamosh A, Dey S, McIntosh I, Dietz HC Proc Natl Acad Sci U S A. 2002 Jan 22. 99(2):856-61. PubMed Journal
Articles Citing Klotho (membrane)
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| Effect of systemically increasing human full-length Klotho on glucose metabolism in db/db mice. Forsberg EA, Olauson H, Larsson T, Catrina SB. Diabetes Res Clin Pract. 2016 Jan 15. pii: S0168-8227(16)00025-5. doi: 10.1016/j.diabres.2016.01.006. PubMed |
| Establishment of Transgenic Porcine Fibroblasts Expressing a Human klotho Gene and Its Effects on Gene Expression and Preimplantation Development of Cloned Embryos. Lee S, Moon JH, Song K, Taweechaipaisankul A, Jo YK, Oh HJ, Park SC, Lee BC. DNA Cell Biol. 2017 Jan;36(1):42-49. doi: 10.1089/dna.2016.3482. Epub 2016 Dec 22. PubMed |
| Protective role of klotho protein on epithelial cells upon co-culture with activated or senescent monocytes. Mytych J, Wos I, Solek P, Koziorowski M. Exp Cell Res. 2017 Jan 15;350(2):358-367. doi: 10.1016/j.yexcr.2016.12.013. Epub 2016 Dec 21. PubMed |
| Klotho down-regulates Egr-1 by inhibiting TGF-beta1/Smad3 signaling in high glucose treated human mesangial cells. Li Y, Hu F, Xue M, Jia YJ, Zheng ZJ, Wang L, Guan MP, Xue YM. Biochem Biophys Res Commun. 2017 May 27;487(2):216-222. doi: 10.1016/j.bbrc.2017.04.036. Epub 2017 Apr 12. PubMed |
| Klotho protects human monocytes from LPS-induced immune impairment associated with immunosenescent-like phenotype. Mytych J, Romerowicz-Misielak M, Koziorowski M. Mol Cell Endocrinol. 2017 May 3. pii: S0303-7207(17)30251-4. doi: 10.1016/j.mce.2017.05.003. PubMed |
| FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts. Smith ER, Tan SJ, Holt SG, Hewitson TD. Sci Rep. 2017 Jun 13;7(1):3345. doi: 10.1038/s41598-017-02709-w. PubMed |
| FGF23 activates injury-primed renal fibroblasts via FGFR4-dependent signalling and enhancement of TGF-beta autoinduction. Smith ER, Holt SG, Hewitson TD. Int J Biochem Cell Biol. 2017 Nov;92:63-78. doi: 10.1016/j.biocel.2017.09.009. Epub 2017 Sep 15. PubMed |
| Extracellular Vesicles from Albumin-Induced Tubular Epithelial Cells Promote the M1 Macrophage Phenotype by Targeting Klotho. Jia Y, Zheng Z, Xue M, Zhang S, Hu F, Li Y, Yang Y, Zou M, Li S, Wang L, Guan M, Xue Y. Mol Ther. 2019 Aug 7;27(8):1452-1466. doi: 10.1016/j.ymthe.2019.05.019. Epub 2019 Jun 4. PubMed |
| FGF23 expression is stimulated in transgenic alpha-Klotho longevity mouse model. Xiao Z, King G, Mancarella S, Munkhsaikhan U, Cao L, Cai C, Quarles LD. JCI Insight. 2019 Dec 5;4(23). pii: 132820. doi: 10.1172/jci.insight.132820. PubMed |
| Towards Age-Related Anti-Inflammatory Therapy: Klotho Suppresses Activation of ER and Golgi Stress Response in Senescent Monocytes. Mytych J, Solek P, Bedzinska A, Rusinek K, Warzybok A, Tabecka-Lonczynska A, Koziorowski M. Cells. 2020 Jan 21;9(2). pii: cells9020261. doi: 10.3390/cells9020261. PubMed |
| Long noncoding RNA NEAT1 is involved in the protective effect of Klotho on renal tubular epithelial cells in diabetic kidney disease through the ERK1/2 signaling pathway. Yang YL, Xue M, Jia YJ, Hu F, Zheng ZJ, Wang L, Si ZK, Xue YM. Exp Mol Med. 2020 Feb;52(2):266-280. doi: 10.1038/s12276-020-0381-5. Epub 2020 Feb 14. PubMed |
| Klotho Exerts an Emerging Role in Cytokinesis. Sun CY, Chou CY, Hsieh YY, Lo KC, Liou YL, Chen YH. Genes (Basel). 2020 Sep 4;11(9). pii: genes11091048. doi: 10.3390/genes11091048. PubMed |
| Klotho prevents epithelial-mesenchymal transition through Egr-1 downregulation in diabetic kidney disease. Li Y, Xue M, Hu F, Jia Y, Zheng Z, Yang Y, Liu X, Yang Y, Wang Y. BMJ Open Diabetes Res Care. 2021 Jun;9(1). pii: 9/1/e002038. doi: 10.1136/bmjdrc-2020-002038. PubMed |
| Angiotensin II receptor type 1 blockade regulates Klotho expression to induce TSC2-deficient cell death. Shrestha S, Adib E, Imani J, Aguiar DJ, Lamattina AM, Tassew DD, Henske EP, Perrella MA, Priolo C, El-Chemaly S. J Biol Chem. 2022 Nov;298(11):102580. doi: 10.1016/j.jbc.2022.102580. Epub 2022 Oct 8. PubMed |
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