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HA-HIF1alpha P402A/P564A-pcDNA3 Citations (36)

Plasmid Article: The hypoxia-inducible factor 2alpha N-terminal and C-terminal transactivation domains cooperate to promote renal tumorigenesis in vivo.
Yan Q, Bartz S, Mao M, Li L, Kaelin WG Mol Cell Biol. 2007 Mar . 27(6):2092-102.
PubMed Journal

Articles Citing HA-HIF1alpha P402A/P564A-pcDNA3

NF-kappaB suppresses HIF-1alpha response by competing for P300 binding. Mendonca DB, Mendonca G, Aragao FJ, Cooper LF. Biochem Biophys Res Commun. 2011 Jan 28;404(4):997-1003. doi: 10.1016/j.bbrc.2010.12.098. Epub 2010 Dec 25. PubMed
Interdependence of HIF-1alpha and TGF-beta/Smad3 signaling in normoxic and hypoxic renal epithelial cell collagen expression. Basu RK, Hubchak S, Hayashida T, Runyan CE, Schumacker PT, Schnaper HW. Am J Physiol Renal Physiol. 2011 Apr;300(4):F898-905. doi: 10.1152/ajprenal.00335.2010. Epub 2011 Jan 5. PubMed
Astrocyte pVHL and HIF-alpha isoforms are required for embryonic-to-adult vascular transition in the eye. Kurihara T, Westenskow PD, Krohne TU, Aguilar E, Johnson RS, Friedlander M. J Cell Biol. 2011 Nov 14;195(4):689-701. doi: 10.1083/jcb.201107029. PubMed
Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1alpha activity in hypoxia. Fujita N, Markova D, Anderson DG, Chiba K, Toyama Y, Shapiro IM, Risbud MV. J Biol Chem. 2012 May 11;287(20):16975-86. doi: 10.1074/jbc.M111.334466. Epub 2012 Mar 26. PubMed
The transcription of the alarmin cytokine interleukin-1 alpha is controlled by hypoxia inducible factors 1 and 2 alpha in hypoxic cells. Rider P, Kaplanov I, Romzova M, Bernardis L, Braiman A, Voronov E, Apte RN. Front Immunol. 2012 Sep 14;3:290. doi: 10.3389/fimmu.2012.00290. eCollection 2012. PubMed
Hypoxia-inducible factor (HIF)-1alpha and CCN2 form a regulatory circuit in hypoxic nucleus pulposus cells: CCN2 suppresses HIF-1alpha level and transcriptional activity. Tran CM, Fujita N, Huang BL, Ong JR, Lyons KM, Shapiro IM, Risbud MV. J Biol Chem. 2013 May 3;288(18):12654-66. doi: 10.1074/jbc.M112.448860. Epub 2013 Mar 24. PubMed
TGF-beta/Smad3 activates mammalian target of rapamycin complex-1 to promote collagen production by increasing HIF-1alpha expression. Rozen-Zvi B, Hayashida T, Hubchak SC, Hanna C, Platanias LC, Schnaper HW. Am J Physiol Renal Physiol. 2013 Aug 15;305(4):F485-94. doi: 10.1152/ajprenal.00215.2013. Epub 2013 Jun 12. PubMed
Hypoxia-inducible factor-2alpha and TGF-beta signaling interact to promote normoxic glomerular fibrogenesis. Hanna C, Hubchak SC, Liang X, Rozen-Zvi B, Schumacker PT, Hayashida T, Schnaper HW. Am J Physiol Renal Physiol. 2013 Nov 1;305(9):F1323-31. doi: 10.1152/ajprenal.00155.2013. Epub 2013 Aug 14. PubMed
Gramicidin A induces metabolic dysfunction and energy depletion leading to cell death in renal cell carcinoma cells. David JM, Owens TA, Barwe SP, Rajasekaran AK. Mol Cancer Ther. 2013 Nov;12(11):2296-307. doi: 10.1158/1535-7163.MCT-13-0445. Epub 2013 Sep 4. PubMed
Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes. Taniguchi CM, Finger EC, Krieg AJ, Wu C, Diep AN, LaGory EL, Wei K, McGinnis LM, Yuan J, Kuo CJ, Giaccia AJ. Nat Med. 2013 Oct;19(10):1325-30. doi: 10.1038/nm.3294. Epub 2013 Sep 15. PubMed
Combined targeting of PDK1 and EGFR triggers regression of glioblastoma by reversing the Warburg effect. Velpula KK, Bhasin A, Asuthkar S, Tsung AJ. Cancer Res. 2013 Dec 15;73(24):7277-89. doi: 10.1158/0008-5472.CAN-13-1868. Epub 2013 Oct 22. PubMed
Paradoxical regulation of hypoxia inducible factor-1alpha (HIF-1alpha) by histone deacetylase inhibitor in diffuse large B-cell lymphoma. Bhalla S, Evens AM, Prachand S, Schumacker PT, Gordon LI. PLoS One. 2013 Nov 27;8(11):e81333. doi: 10.1371/journal.pone.0081333. eCollection 2013. PubMed
Gramicidin A blocks tumor growth and angiogenesis through inhibition of hypoxia-inducible factor in renal cell carcinoma. David JM, Owens TA, Inge LJ, Bremner RM, Rajasekaran AK. Mol Cancer Ther. 2014 Apr;13(4):788-99. doi: 10.1158/1535-7163.MCT-13-0891. Epub 2014 Feb 3. PubMed
HIF-1alpha downregulation and apoptosis in hypoxic prostate tumor cells infected with oncolytic mammalian orthoreovirus. Gupta-Saraf P, Miller CL. Oncotarget. 2014 Jan 30;5(2):561-74. PubMed
Convergence of hypoxia and TGFbeta pathways on cell cycle regulation in human hematopoietic stem/progenitor cells. Wierenga AT, Vellenga E, Schuringa JJ. PLoS One. 2014 Mar 31;9(3):e93494. doi: 10.1371/journal.pone.0093494. eCollection 2014. PubMed
Hypoxia reduces and redirects selenoprotein biosynthesis. Becker NP, Martitz J, Renko K, Stoedter M, Hybsier S, Cramer T, Schomburg L. Metallomics. 2014 May;6(5):1079-86. doi: 10.1039/c4mt00004h. PubMed
Dynamin 2 along with microRNA-199a reciprocally regulate hypoxia-inducible factors and ovarian cancer metastasis. Joshi HP, Subramanian IV, Schnettler EK, Ghosh G, Rupaimoole R, Evans C, Saluja M, Jing Y, Cristina I, Roy S, Zeng Y, Shah VH, Sood AK, Ramakrishnan S. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5331-6. doi: 10.1073/pnas.1317242111. Epub 2014 Mar 24. PubMed
Hypoxia-inducible factor-1alpha induces ErbB4 signaling in the differentiating mammary gland. Paatero I, Seagroves TN, Vaparanta K, Han W, Jones FE, Johnson RS, Elenius K. J Biol Chem. 2014 Aug 8;289(32):22459-69. doi: 10.1074/jbc.M113.533497. Epub 2014 Jun 25. PubMed
Hypoxia promotes colon cancer dissemination through up-regulation of cell migration-inducing protein (CEMIP). Evensen NA, Li Y, Kuscu C, Liu J, Cathcart J, Banach A, Zhang Q, Li E, Joshi S, Yang J, Denoya PI, Pastorekova S, Zucker S, Shroyer KR, Cao J. Oncotarget. 2015 Aug 21;6(24):20723-39. PubMed
Estrogen Receptor beta2 Induces Hypoxia Signature of Gene Expression by Stabilizing HIF-1alpha in Prostate Cancer. Dey P, Velazquez-Villegas LA, Faria M, Turner A, Jonsson P, Webb P, Williams C, Gustafsson JA, Strom AM. PLoS One. 2015 May 26;10(5):e0128239. doi: 10.1371/journal.pone.0128239. eCollection 2015. PubMed
HIF-1alpha/MDR1 pathway confers chemoresistance to cisplatin in bladder cancer. Sun Y, Guan Z, Liang L, Cheng Y, Zhou J, Li J, Xu Y. Oncol Rep. 2015 Dec 29. doi: 10.3892/or.2015.4536. PubMed
Hypoxia-inducible factor-1alpha promotes glomerulosclerosis and regulates COL1A2 expression through interactions with Smad3. Baumann B, Hayashida T, Liang X, Schnaper HW. Kidney Int. 2016 Oct;90(4):797-808. doi: 10.1016/j.kint.2016.05.026. Epub 2016 Aug 5. PubMed
FGF11 induced by hypoxia interacts with HIF-1alpha and enhances its stability. Lee KW, Yim HS, Shin J, Lee C, Lee JH, Jeong JY. FEBS Lett. 2016 Dec 27. doi: 10.1002/1873-3468.12547. PubMed
GATA3 interacts with and stabilizes HIF-1alpha to enhance cancer cell invasiveness. Lin MC, Lin JJ, Hsu CL, Juan HF, Lou PJ, Huang MC. Oncogene. 2017 Jul 27;36(30):4243-4252. doi: 10.1038/onc.2017.8. Epub 2017 Mar 6. PubMed
Amplified centrosomes and mitotic index display poor concordance between patient tumors and cultured cancer cells. Mittal K, Choi DH, Ogden A, Donthamsetty S, Melton BD, Gupta MV, Pannu V, Cantuaria G, Varambally S, Reid MD, Jonsdottir K, Janssen EA, Aleskandarany MA, Ellis IO, Rakha EA, Rida PC, Aneja R. Sci Rep. 2017 Mar 8;7:43984. doi: 10.1038/srep43984. PubMed
Nkx3.2 induces oxygen concentration-independent and lysosome-dependent degradation of HIF-1alpha to modulate hypoxic responses in chondrocytes. Im S, Kim DW. Cell Signal. 2017 Aug;36:127-138. doi: 10.1016/j.cellsig.2017.05.001. Epub 2017 May 4. PubMed
Hypoxia-inducible factor-1alpha plays roles in Epstein-Barr virus's natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter. Kraus RJ, Yu X, Cordes BA, Sathiamoorthi S, Iempridee T, Nawandar DM, Ma S, Romero-Masters JC, McChesney KG, Lin Z, Makielski KR, Lee DL, Lambert PF, Johannsen EC, Kenney SC, Mertz JE. PLoS Pathog. 2017 Jun 15;13(6):e1006404. doi: 10.1371/journal.ppat.1006404. eCollection 2017 Jun. PubMed
XIAP upregulates expression of HIF target genes by targeting HIF1alpha for Lys63-linked polyubiquitination. Park CV, Ivanova IG, Kenneth NS. Nucleic Acids Res. 2017 Jun 28. doi: 10.1093/nar/gkx549. PubMed
Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1. Rosner M, Pham HTT, Moriggl R, Hengstschlager M. Nat Commun. 2017 Sep 19;8(1):595. doi: 10.1038/s41467-017-00661-x. PubMed
HIF1-alpha expressing cells induce a hypoxic-like response in neighbouring cancer cells. Harrison H, Pegg HJ, Thompson J, Bates C, Shore P. BMC Cancer. 2018 Jun 20;18(1):674. doi: 10.1186/s12885-018-4577-1. PubMed
Macrophage-Specific Hypoxia-Inducible Factor-1alpha Contributes to Impaired Autophagic Flux in Nonalcoholic Steatohepatitis. Wang X, de Carvalho Ribeiro M, Iracheta-Vellve A, Lowe P, Ambade A, Satishchandran A, Bukong T, Catalano D, Kodys K, Szabo G. Hepatology. 2019 Feb;69(2):545-563. doi: 10.1002/hep.30215. Epub 2019 Jan 4. PubMed
Resveratrol integrates metabolic and growth effects in PC3 prostate cancer cells-involvement of prolyl hydroxylase and hypoxia inducible factor-1. Fonseca J, Moradi F, Maddalena LA, Ferreira-Tollstadius B, Selim S, Stuart JA. Oncol Lett. 2019 Jan;17(1):697-705. doi: 10.3892/ol.2018.9526. Epub 2018 Sep 28. PubMed
MYC Regulates the HIF2alpha Stemness Pathway via Nanog and Sox2 to Maintain Self-Renewal in Cancer Stem Cells versus Non-Stem Cancer Cells. Das B, Pal B, Bhuyan R, Li H, Sarma A, Gayan S, Talukdar J, Sandhya S, Bhuyan S, Gogoi G, Gouw AM, Baishya D, Gotlib JR, Kataki AC, Felsher DW. Cancer Res. 2019 Jul 2. pii: 0008-5472.CAN-18-2847. doi: 10.1158/0008-5472.CAN-18-2847. PubMed
A hierarchical network of hypoxia-inducible factor and SMAD proteins governs procollagen lysyl hydroxylase 2 induction by hypoxia and transforming growth factor beta1. Rosell-Garcia T, Palomo-Alvarez O, Rodriguez-Pascual F. J Biol Chem. 2019 Sep 27;294(39):14308-14318. doi: 10.1074/jbc.RA119.007674. Epub 2019 Aug 7. PubMed
Metabolic Rewiring in Response to Biguanides Is Mediated by mROS/HIF-1a in Malignant Lymphocytes. Khan H, Anshu A, Prasad A, Roy S, Jeffery J, Kittipongdaja W, Yang DT, Schieke SM. Cell Rep. 2019 Dec 3;29(10):3009-3018.e4. doi: 10.1016/j.celrep.2019.11.007. PubMed
Non-viral gene delivery of HIF-1alpha promotes angiogenesis in human adipose-derived stem cells. Est-Witte SE, Farris AL, Tzeng SY, Hutton DL, Gong DH, Calabresi KG, Grayson WL, Green JJ. Acta Biomater. 2020 Sep 1;113:279-288. doi: 10.1016/j.actbio.2020.06.042. Epub 2020 Jul 2. PubMed

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