pCDNA3.1-hMcl-1 Citations (20)

Originally described in: Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis.
Morel C, Carlson SM, White FM, Davis RJ Mol Cell Biol. 2009 Jul . 29(14):3845-52. PubMed Journal

---

Articles Citing pCDNA3.1-hMcl-1

Articles
The novel anti-MEK small molecule AZD6244 induces BIM-dependent and AKT-independent apoptosis in diffuse large B-cell lymphoma. Bhalla S, Evens AM, Dai B, Prachand S, Gordon LI, Gartenhaus RB. Blood. 2011 Jul 28;118(4):1052-61. doi: 10.1182/blood-2011-03-340109. Epub 2011 May 31. PubMed
Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines. Chen CH, Liao CH, Chang YL, Guh JH, Pan SL, Teng CM. Cancer Lett. 2012 Feb 1;315(1):1-11. doi: 10.1016/j.canlet.2011.09.042. Epub 2011 Oct 8. PubMed
Caveolin-1 regulates Mcl-1 stability and anoikis in lung carcinoma cells. Chunhacha P, Pongrakhananon V, Rojanasakul Y, Chanvorachote P. Am J Physiol Cell Physiol. 2012 May 1;302(9):C1284-92. doi: 10.1152/ajpcell.00318.2011. Epub 2012 Jan 25. PubMed
In vitro and in vivo anti-tumour effects of MPT0B014, a novel derivative aroylquinoline, and in combination with erlotinib in human non-small-cell lung cancer cells. Tsai AC, Pai HC, Wang CY, Liou JP, Teng CM, Wang JC, Pan SL. Br J Pharmacol. 2014 Jan;171(1):122-33. doi: 10.1111/bph.12427. PubMed
Orally active microtubule-targeting agent, MPT0B271, for the treatment of human non-small cell lung cancer, alone and in combination with erlotinib. Tsai AC, Wang CY, Liou JP, Pai HC, Hsiao CJ, Chang JY, Wang JC, Teng CM, Pan SL. Cell Death Dis. 2014 Apr 10;5:e1162. doi: 10.1038/cddis.2014.128. PubMed
PI3K and Bcl-2 inhibition primes glioblastoma cells to apoptosis through downregulation of Mcl-1 and Phospho-BAD. Pareja F, Macleod D, Shu C, Crary JF, Canoll PD, Ross AH, Siegelin MD. Mol Cancer Res. 2014 Jul;12(7):987-1001. doi: 10.1158/1541-7786.MCR-13-0650. Epub 2014 Apr 22. PubMed
RFX1-dependent activation of SHP-1 induces autophagy by a novel obatoclax derivative in hepatocellular carcinoma cells. Su JC, Tseng PH, Hsu CY, Tai WT, Huang JW, Ko CH, Lin MW, Liu CY, Chen KF, Shiau CW. Oncotarget. 2014 Jul 15;5(13):4909-19. PubMed
Early downregulation of Mcl-1 regulates apoptosis triggered by cardiac glycoside UNBS1450. Cerella C, Muller F, Gaigneaux A, Radogna F, Viry E, Chateauvieux S, Dicato M, Diederich M. Cell Death Dis. 2015 Jun 11;6:e1782. doi: 10.1038/cddis.2015.134. PubMed
Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress. Leclerc GJ, DeSalvo J, Du J, Gao N, Leclerc GM, Lehrman MA, Lampidis TJ, Barredo JC. Leuk Res. 2015 Aug 20. pii: S0145-2126(15)30360-X. doi: 10.1016/j.leukres.2015.08.007. PubMed
Identification of a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain. Iyer D, Vartak SV, Mishra A, Goldsmith G, Kumar S, Srivastava M, Hegde M, Gopalakrishnan V, Glenn M, Velusamy M, Choudhary B, Kalakonda N, Karki SS, Surolia A, Raghavan SC. FEBS J. 2016 Sep;283(18):3408-37. doi: 10.1111/febs.13815. Epub 2016 Aug 17. PubMed
A conformational switch regulates the ubiquitin ligase HUWE1. Sander B, Xu W, Eilers M, Popov N, Lorenz S. Elife. 2017 Feb 14;6. doi: 10.7554/eLife.21036. PubMed
Alcohol-Mediated Missplicing of Mcl-1 Pre-mRNA is Involved in Neurotoxicity. Sariyer R, De-Simone FI, Donadoni M, Hoek JB, Chang SL, Sariyer IK. Alcohol Clin Exp Res. 2017 Oct;41(10):1715-1724. doi: 10.1111/acer.13474. Epub 2017 Sep 1. PubMed
Reactive oxygen species mediate cancer stem-like cells and determine bortezomib sensitivity via Mcl-1 and Zeb-1 in mantle cell lymphoma. Luanpitpong S, Poohadsuan J, Samart P, Kiratipaiboon C, Rojanasakul Y, Issaragrisil S. Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3739-3753. doi: 10.1016/j.bbadis.2018.09.010. Epub 2018 Sep 11. PubMed
Combined inhibition of the PI3K/mTOR/MEK pathway induces Bim/Mcl-1-regulated apoptosis in pancreatic cancer cells. Burmi RS, Maginn EN, Gabra H, Stronach EA, Wasan HS. Cancer Biol Ther. 2019;20(1):21-30. doi: 10.1080/15384047.2018.1504718. Epub 2018 Sep 27. PubMed
Inhibition of cyclin E1 overcomes temozolomide resistance in glioblastoma by Mcl-1 degradation. Liang H, Chen Z, Sun L. Mol Carcinog. 2019 Aug;58(8):1502-1511. doi: 10.1002/mc.23034. Epub 2019 May 2. PubMed
Inhibition of cyclin E1 sensitizes hepatocellular carcinoma cells to regorafenib by mcl-1 suppression. Xu J, Huang F, Yao Z, Jia C, Xiong Z, Liang H, Lin N, Deng M. Cell Commun Signal. 2019 Jul 26;17(1):85. doi: 10.1186/s12964-019-0398-3. PubMed
AMPK activation overcomes anti-EGFR antibody resistance induced by KRAS mutation in colorectal cancer. Ye H, Liu Y, Wu K, Luo H, Cui L. Cell Commun Signal. 2020 Jul 23;18(1):115. doi: 10.1186/s12964-020-00584-z. PubMed
Epigenetic Targeting of Mcl-1 Is Synthetically Lethal with Bcl-xL/Bcl-2 Inhibition in Model Systems of Glioblastoma. Shang E, Nguyen TTT, Shu C, Westhoff MA, Karpel-Massler G, Siegelin MD. Cancers (Basel). 2020 Aug 1;12(8). pii: cancers12082137. doi: 10.3390/cancers12082137. PubMed
Role of phloretin as a sensitizer to TRAIL-induced apoptosis in colon cancer. Kim JL, Lee DH, Pan CH, Park SJ, Oh SC, Lee SY. Oncol Lett. 2022 Jul 19;24(3):321. doi: 10.3892/ol.2022.13441. eCollection 2022 Sep. PubMed
Intracellular BAPTA directly inhibits PFKFB3, thereby impeding mTORC1-driven Mcl-1 translation and killing MCL-1-addicted cancer cells. Sneyers F, Kerkhofs M, Speelman-Rooms F, Welkenhuyzen K, La Rovere R, Shemy A, Voet A, Eelen G, Dewerchin M, Tait SWG, Ghesquiere B, Bootman MD, Bultynck G. Cell Death Dis. 2023 Sep 8;14(9):600. doi: 10.1038/s41419-023-06120-4. PubMed

If you have published an article using this material, please email us at to have your article added to this page.