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pAAV asyn WT Citations (8)

Originally described in: Mimicking phosphorylation at serine 87 inhibits the aggregation of human alpha-synuclein and protects against its toxicity in a rat model of Parkinson's disease.
Oueslati A, Paleologou KE, Schneider BL, Aebischer P, Lashuel HA J Neurosci. 2012 Feb 1;32(5):1536-44.
PubMed Journal

Articles Citing pAAV asyn WT

Lanosterol Suppresses the Aggregation and Cytotoxicity of Misfolded Proteins Linked with Neurodegenerative Diseases. Upadhyay A, Amanullah A, Mishra R, Kumar A, Mishra A. Mol Neurobiol. 2017 Jan 19. doi: 10.1007/s12035-016-0377-2. PubMed
Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T alpha-synuclein model of Parkinson's disease. Chen J, Ren Y, Gui C, Zhao M, Wu X, Mao K, Li W, Zou F. Cell Death Dis. 2018 Jun 13;9(6):700. doi: 10.1038/s41419-018-0722-7. PubMed
Polyphenolic flavonoid (Myricetin) upregulated proteasomal degradation mechanisms: Eliminates neurodegenerative proteins aggregation. Joshi V, Mishra R, Upadhyay A, Amanullah A, Poluri KM, Singh S, Kumar A, Mishra A. J Cell Physiol. 2019 Nov;234(11):20900-20914. doi: 10.1002/jcp.28695. Epub 2019 Apr 19. PubMed
Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: What you see is not always what you get. Frey B, AlOkda A, Jackson MP, Riguet N, Duce JA, Lashuel HA. J Neurochem. 2021 May;157(4):872-888. doi: 10.1111/jnc.15147. Epub 2020 Oct 27. PubMed
p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease. Chen J, Mao K, Yu H, Wen Y, She H, Zhang H, Liu L, Li M, Li W, Zou F. J Neuroinflammation. 2021 Dec 20;18(1):295. doi: 10.1186/s12974-021-02349-y. PubMed
Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity. Lashuel HA, Mahul-Mellier AL, Novello S, Hegde RN, Jasiqi Y, Altay MF, Donzelli S, DeGuire SM, Burai R, Magalhaes P, Chiki A, Ricci J, Boussouf M, Sadek A, Stoops E, Iseli C, Guex N. NPJ Parkinsons Dis. 2022 Oct 20;8(1):136. doi: 10.1038/s41531-022-00388-7. PubMed
Ubiquilin-2 regulates pathological alpha-synuclein. Sandoval-Pistorius SS, Gerson JE, Liggans N, Ryou JH, Oak K, Li X, Negron-Rios KY, Fischer S, Barsh H, Crowley EV, Skinner ME, Sharkey LM, Barmada SJ, Paulson HL. Sci Rep. 2023 Jan 6;13(1):293. doi: 10.1038/s41598-022-26899-0. PubMed
Itraconazole Confers Cytoprotection Against Neurodegenerative Disease-Associated Abnormal Protein Aggregation. Dubey AR, Mishra R, Jagtap YA, Kinger S, Kumar P, Dhiman R, Ghosh S, Singh S, Prasad A, Jana NR, Mishra A. Mol Neurobiol. 2023 May;60(5):2397-2412. doi: 10.1007/s12035-023-03230-0. Epub 2023 Jan 19. PubMed

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