Skip to main content
This website uses cookies to ensure you get the best experience. By continuing to use this site, you agree to the use of cookies.
We will increase some of our prices at 12:00 AM ET on April 1, 2023. Be sure to complete your order before this time to take advantage of current prices. See the new prices and get more information or speak with our friendly support team.

Please note: Your browser does not support the features used on Addgene's website. You may not be able to create an account or request plasmids through this website until you upgrade your browser. Learn more

Please note: Your browser does not fully support some of the features used on Addgene's website. If you run into any problems registering, depositing, or ordering please contact us at [email protected] Learn more

NC16 pCDNA3.1 FLAG NRF2 Citations (24)

Plasmid Article: Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein.
Camp ND, James RG, Dawson DW, Yan F, Davison JM, Houck SA, Tang X, Zheng N, Major MB, Moon RT J Biol Chem. 2012 Feb 24;287(9):6539-50. Epub 2012 Jan 3.
PubMed Journal

Articles Citing NC16 pCDNA3.1 FLAG NRF2

Oxidative stress regulates CFTR gene expression in human airway epithelial cells through a distal antioxidant response element. Zhang Z, Leir SH, Harris A. Am J Respir Cell Mol Biol. 2015 Mar;52(3):387-96. doi: 10.1165/rcmb.2014-0263OC. PubMed
p38 MAPK-dependent Nrf2 induction enhances the resistance of glioma cells against TMZ. Ma L, Liu J, Zhang X, Qi J, Yu W, Gu Y. Med Oncol. 2015 Mar;32(3):69. doi: 10.1007/s12032-015-0517-y. Epub 2015 Feb 19. PubMed
Assays for induction of the unfolded protein response and selective activation of the three major pathways. Gupta A, Read DE, Gupta S. Methods Mol Biol. 2015;1292:19-38. doi: 10.1007/978-1-4939-2522-3_2. PubMed
NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK-eIF2alpha-ATF4 signalling in breast cancer. Gupta A, Hossain MM, Miller N, Kerin M, Callagy G, Gupta S. Oncogene. 2016 Apr 25. doi: 10.1038/onc.2016.121. PubMed
Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma. Ahmad F, Dixit D, Sharma V, Kumar A, Joshi SD, Sarkar C, Sen E. Cell Death Dis. 2016 May 5;7:e2213. doi: 10.1038/cddis.2016.117. PubMed
Intermittent hypoxia confers pro-metastatic gene expression selectively through NF-kappaB in inflammatory breast cancer cells. Gutsche K, Randi EB, Blank V, Fink D, Wenger RH, Leo C, Scholz CC. Free Radic Biol Med. 2016 Dec;101:129-142. doi: 10.1016/j.freeradbiomed.2016.10.002. Epub 2016 Oct 5. PubMed
Nrf2 Transcription Factor Can Directly Regulate mTOR: LINKING CYTOPROTECTIVE GENE EXPRESSION TO A MAJOR METABOLIC REGULATOR THAT GENERATES REDOX ACTIVITY. Bendavit G, Aboulkassim T, Hilmi K, Shah S, Batist G. J Biol Chem. 2016 Dec 2;291(49):25476-25488. Epub 2016 Oct 26. PubMed
Dimethyl fumarate controls the NRF2/DJ-1 axis in cancer cells: therapeutic applications. Saidu NE, Noe G, Cerles O, Cabel L, Kavian-Tessler N, Chouzenoux S, Bahuaud M, Chereau C, Nicco C, Leroy K, Borghese B, Goldwasser F, Batteux F, Alexandre J. Mol Cancer Ther. 2017 Jan 9. pii: molcanther.0405.2016. doi: 10.1158/1535-7163.MCT-16-0405. PubMed
Various Mechanisms Involve the Nuclear Factor (Erythroid-Derived 2)-Like (NRF2) to Achieve Cytoprotection in Long-Term Cisplatin-Treated Urothelial Carcinoma Cell Lines. Skowron MA, Niegisch G, Albrecht P, van Koeveringe G, Romano A, Albers P, Schulz WA, Hoffmann MJ. Int J Mol Sci. 2017 Aug 2;18(8). pii: ijms18081680. doi: 10.3390/ijms18081680. PubMed
Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance. Takahashi N, Chen HY, Harris IS, Stover DG, Selfors LM, Bronson RT, Deraedt T, Cichowski K, Welm AL, Mori Y, Mills GB, Brugge JS. Cancer Cell. 2018 Jun 11;33(6):985-1003.e7. doi: 10.1016/j.ccell.2018.05.001. Epub 2018 May 24. PubMed
TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy. Jena KK, Kolapalli SP, Mehto S, Nath P, Das B, Sahoo PK, Ahad A, Syed GH, Raghav SK, Senapati S, Chauhan S, Chauhan S. EMBO J. 2018 Sep 14;37(18). pii: embj.201798358. doi: 10.15252/embj.201798358. Epub 2018 Aug 24. PubMed
NRF2 transcriptionally activates the heat shock factor 1 promoter under oxidative stress and affects survival and migration potential of MCF7 cells. Paul S, Ghosh S, Mandal S, Sau S, Pal M. J Biol Chem. 2018 Dec 14;293(50):19303-19316. doi: 10.1074/jbc.RA118.003376. Epub 2018 Oct 11. PubMed
Targeting NFE2L2, a transcription factor upstream of MMP-2: A potential therapeutic strategy for temozolomide resistant glioblastoma. Rajesh Y, Biswas A, Kumar U, Das S, Banerjee I, Banik P, Bharti R, Nayak S, Ghosh SK, Mandal M. Biochem Pharmacol. 2019 Jun;164:1-16. doi: 10.1016/j.bcp.2019.03.025. Epub 2019 Mar 15. PubMed
Increased expression of NAF1 contributes to malignant phenotypes of glioma cells through promoting protein synthesis and associates with poor patient survival. Wei J, Yang Q, Shi J, Shi B, Ji M, Hou P. Oncogenesis. 2019 Apr 1;8(4):25. doi: 10.1038/s41389-019-0134-2. PubMed
Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition. Towers CG, Fitzwalter BE, Regan D, Goodspeed A, Morgan MJ, Liu CW, Gustafson DL, Thorburn A. Dev Cell. 2019 Sep 23;50(6):690-703.e6. doi: 10.1016/j.devcel.2019.07.010. Epub 2019 Aug 1. PubMed
AMPK leads to phosphorylation of the transcription factor Nrf2, tuning transactivation of selected target genes. Matzinger M, Fischhuber K, Poloske D, Mechtler K, Heiss EH. Redox Biol. 2020 Jan;29:101393. doi: 10.1016/j.redox.2019.101393. Epub 2019 Nov 27. PubMed
The acetyltransferase p300 regulates NRF2 stability and localization. Ganner A, Pfeiffer ZC, Wingendorf L, Kreis S, Klein M, Walz G, Neumann-Haefelin E. Biochem Biophys Res Commun. 2020 Apr 16;524(4):895-902. doi: 10.1016/j.bbrc.2020.02.006. Epub 2020 Feb 10. PubMed
CR6 interacting factor 1 deficiency induces premature senescence via SIRT3 inhibition in endothelial cells. Kim S, Piao S, Lee I, Nagar H, Choi SJ, Shin N, Kim DW, Shong M, Jeon BH, Kim CS. Free Radic Biol Med. 2020 Apr;150:161-171. doi: 10.1016/j.freeradbiomed.2020.02.017. Epub 2020 Feb 25. PubMed
ATF4-Dependent NRF2 Transcriptional Regulation Promotes Antioxidant Protection during Endoplasmic Reticulum Stress. Sarcinelli C, Dragic H, Piecyk M, Barbet V, Duret C, Barthelaix A, Ferraro-Peyret C, Fauvre J, Renno T, Chaveroux C, Manie SN. Cancers (Basel). 2020 Mar 1;12(3). pii: cancers12030569. doi: 10.3390/cancers12030569. PubMed
The stress response protein REDD1 promotes diabetes-induced oxidative stress in the retina by Keap1-independent Nrf2 degradation. Miller WP, Sunilkumar S, Giordano JF, Toro AL, Barber AJ, Dennis MD. J Biol Chem. 2020 May 22;295(21):7350-7361. doi: 10.1074/jbc.RA120.013093. Epub 2020 Apr 15. PubMed
Defining the Functional Targets of Cap'n'collar Transcription Factors NRF1, NRF2, and NRF3. Ibrahim L, Mesgarzadeh J, Xu I, Powers ET, Wiseman RL, Bollong MJ. Antioxidants (Basel). 2020 Oct 21;9(10). pii: antiox9101025. doi: 10.3390/antiox9101025. PubMed
Eugenol protects cells against oxidative stress via Nrf2. Ma L, Liu J, Lin Q, Gu Y, Yu W. Exp Ther Med. 2021 Feb;21(2):107. doi: 10.3892/etm.2020.9539. Epub 2020 Nov 27. PubMed
SUMO-Modification of Human Nrf2 at K(110) and K(533) Regulates Its Nucleocytoplasmic Localization, Stability and Transcriptional Activity. Walters TS, McIntosh DJ, Ingram SM, Tillery L, Motley ED, Arinze IJ, Misra S. Cell Physiol Biochem. 2021 Mar 27;55(2):141-159. doi: 10.33594/000000351. PubMed
The Expression of TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Can Be Controlled by the Antioxidant Orchestrator NRF2 in Human Carcinoma Cells. Simon-Molas H, Sanchez-de-Diego C, Navarro-Sabate A, Castano E, Ventura F, Bartrons R, Manzano A. Int J Mol Sci. 2022 Feb 8;23(3). pii: ijms23031905. doi: 10.3390/ijms23031905. PubMed

If you have published an article using this plasmid, please email us at [email protected] to have your article added to this page.