EGFP-alphasynuclein-A53T Citations (36)
Originally described in: Alpha-synuclein overexpression promotes aggregation of mutant huntingtin.Furlong RA, Narain Y, Rankin J, Wyttenbach A, Rubinsztein DC Biochem J. 2000 Mar 15;346 Pt 3:577-81. PubMed Journal
Articles Citing EGFP-alphasynuclein-A53T
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| Alpha-synuclein modulates retinal iron homeostasis by facilitating the uptake of transferrin-bound iron: Implications for visual manifestations of Parkinson's disease. Baksi S, Tripathi AK, Singh N. Free Radic Biol Med. 2016 Jun 23;97:292-306. doi: 10.1016/j.freeradbiomed.2016.06.025. PubMed |
| alpha-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson's disease patients. Dieriks BV, Park TI, Fourie C, Faull RL, Dragunow M, Curtis MA. Sci Rep. 2017 Feb 23;7:42984. doi: 10.1038/srep42984. PubMed |
| Accumulation of autophagosomes confers cytotoxicity. Button RW, Roberts SL, Willis TL, Hanemann CO, Luo S. J Biol Chem. 2017 Jul 3. pii: jbc.M117.782276. doi: 10.1074/jbc.M117.782276. PubMed |
| New compounds identified through in silico approaches reduce the alpha-synuclein expression by inhibiting prolyl oligopeptidase in vitro. Kumar R, Bavi R, Jo MG, Arulalapperumal V, Baek A, Rampogu S, Kim MO, Lee KW. Sci Rep. 2017 Sep 7;7(1):10827. doi: 10.1038/s41598-017-11302-0. PubMed |
| Gintonin Mitigates MPTP-Induced Loss of Nigrostriatal Dopaminergic Neurons and Accumulation of alpha-Synuclein via the Nrf2/HO-1 Pathway. Jo MG, Ikram M, Jo MH, Yoo L, Chung KC, Nah SY, Hwang H, Rhim H, Kim MO. Mol Neurobiol. 2019 Jan;56(1):39-55. doi: 10.1007/s12035-018-1020-1. Epub 2018 Apr 19. PubMed |
| Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T alpha-synuclein model of Parkinson's disease. Chen J, Ren Y, Gui C, Zhao M, Wu X, Mao K, Li W, Zou F. Cell Death Dis. 2018 Jun 13;9(6):700. doi: 10.1038/s41419-018-0722-7. PubMed |
| Alpha-synuclein delays mitophagy and targeting Miro rescues neuron loss in Parkinson's models. Shaltouki A, Hsieh CH, Kim MJ, Wang X. Acta Neuropathol. 2018 Oct;136(4):607-620. doi: 10.1007/s00401-018-1873-4. Epub 2018 Jun 9. PubMed |
| Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity. Hu D, Sun X, Liao X, Zhang X, Zarabi S, Schimmer A, Hong Y, Ford C, Luo Y, Qi X. Acta Neuropathol. 2019 Jun;137(6):939-960. doi: 10.1007/s00401-019-01993-2. Epub 2019 Mar 15. PubMed |
| Gene co-expression analysis of the human substantia nigra identifies BMP2 as a neurotrophic factor that can promote neurite growth in cells overexpressing wild-type or A53T alpha-synuclein. Goulding SR, Sullivan AM, O'Keeffe GW, Collins LM. Parkinsonism Relat Disord. 2019 Apr 11. pii: S1353-8020(19)30203-2. doi: 10.1016/j.parkreldis.2019.04.008. PubMed |
| Gene Co-expression Analysis Identifies Histone Deacetylase 5 and 9 Expression in Midbrain Dopamine Neurons and as Regulators of Neurite Growth via Bone Morphogenetic Protein Signaling. Mazzocchi M, Wyatt SL, Mercatelli D, Morari M, Morales-Prieto N, Collins LM, Sullivan AM, O'Keeffe GW. Front Cell Dev Biol. 2019 Sep 13;7:191. doi: 10.3389/fcell.2019.00191. eCollection 2019. PubMed |
Negative regulation of autophagy by UBA6-BIRC6-mediated ubiquitination of LC3.
Jia R, Bonifacino JS.
Elife. 2019 Nov 6;8. pii: 50034. doi: 10.7554/eLife.50034.
PubMed
Associated Plasmids |
| Unconventional secretion of alpha-Crystallin B requires the Autophagic pathway and is controlled by phosphorylation of its serine 59 residue. D'Agostino M, Scerra G, Cannata Serio M, Caporaso MG, Bonatti S, Renna M. Sci Rep. 2019 Nov 15;9(1):16892. doi: 10.1038/s41598-019-53226-x. PubMed |
| p38 MAPK-DRP1 signaling is involved in mitochondrial dysfunction and cell death in mutant A53T alpha-synuclein model of Parkinson's disease. Gui C, Ren Y, Chen J, Wu X, Mao K, Li H, Yu H, Zou F, Li W. Toxicol Appl Pharmacol. 2020 Feb 1;388:114874. doi: 10.1016/j.taap.2019.114874. Epub 2019 Dec 24. PubMed |
| Alterations in alpha-synuclein and PINK1 expression reduce neurite length and induce mitochondrial fission and Golgi fragmentation in midbrain neurons. Furlong RM, O'Keeffe GW, O'Neill C, Sullivan AM. Neurosci Lett. 2020 Feb 16;720:134777. doi: 10.1016/j.neulet.2020.134777. Epub 2020 Jan 21. PubMed |
| Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes alpha-synuclein degradation via transcription factor EB-dependent autophagy in mutant alpha-synucleinA53T model of Parkinson's disease. Mao K, Chen J, Yu H, Li H, Ren Y, Wu X, Wen Y, Zou F, Li W. Aging Cell. 2020 Jun;19(6):e13163. doi: 10.1111/acel.13163. Epub 2020 May 31. PubMed |
| Endocytic regulation of cellular ion homeostasis controls lysosome biogenesis. Lopez-Hernandez T, Puchkov D, Krause E, Maritzen T, Haucke V. Nat Cell Biol. 2020 Jul;22(7):815-827. doi: 10.1038/s41556-020-0535-7. Epub 2020 Jun 29. PubMed |
The ubiquitin isopeptidase USP10 deubiquitinates LC3B to increase LC3B levels and autophagic activity.
Jia R, Bonifacino JS.
J Biol Chem. 2021 Jan-Jun;296:100405. doi: 10.1016/j.jbc.2021.100405. Epub 2021 Feb 10.
PubMed
Associated Plasmids |
| In situ architecture of neuronal alpha-Synuclein inclusions. Trinkaus VA, Riera-Tur I, Martinez-Sanchez A, Bauerlein FJB, Guo Q, Arzberger T, Baumeister W, Dudanova I, Hipp MS, Hartl FU, Fernandez-Busnadiego R. Nat Commun. 2021 Apr 14;12(1):2110. doi: 10.1038/s41467-021-22108-0. PubMed |
| LMK235, a small molecule inhibitor of HDAC4/5, protects dopaminergic neurons against neurotoxin- and alpha-synuclein-induced degeneration in cellular models of Parkinson's disease. Mazzocchi M, Goulding SR, Wyatt SL, Collins LM, Sullivan AM, O'Keeffe GW. Mol Cell Neurosci. 2021 Sep;115:103642. doi: 10.1016/j.mcn.2021.103642. Epub 2021 Jun 10. PubMed |
| The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model. Yuste-Checa P, Trinkaus VA, Riera-Tur I, Imamoglu R, Schaller TF, Wang H, Dudanova I, Hipp MS, Bracher A, Hartl FU. Nat Commun. 2021 Aug 11;12(1):4863. doi: 10.1038/s41467-021-25060-1. PubMed |
| Genome-wide screen identifies curli amyloid fibril as a bacterial component promoting host neurodegeneration. Wang C, Lau CY, Ma F, Zheng C. Proc Natl Acad Sci U S A. 2021 Aug 24;118(34). pii: 2106504118. doi: 10.1073/pnas.2106504118. PubMed |
| p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease. Chen J, Mao K, Yu H, Wen Y, She H, Zhang H, Liu L, Li M, Li W, Zou F. J Neuroinflammation. 2021 Dec 20;18(1):295. doi: 10.1186/s12974-021-02349-y. PubMed |
| Polygala saponins inhibit NLRP3 inflammasome-mediated neuroinflammation via SHP-2-Mediated mitophagy. Qiu WQ, Ai W, Zhu FD, Zhang Y, Guo MS, Law BY, Wu JM, Wong VK, Tang Y, Yu L, Chen Q, Yu CL, Liu J, Qin DL, Zhou XG, Wu AG. Free Radic Biol Med. 2022 Feb 1;179:76-94. doi: 10.1016/j.freeradbiomed.2021.12.263. Epub 2021 Dec 20. PubMed |
| Roflupram attenuates alpha-synuclein-induced cytotoxicity and promotes the mitochondrial translocation of Parkin in SH-SY5Y cells overexpressing A53T mutant alpha-synuclein. Zhong J, Li M, Xu J, Dong W, Qin Y, Qiu S, Li X, Wang H. Toxicol Appl Pharmacol. 2022 Feb 1;436:115859. doi: 10.1016/j.taap.2021.115859. Epub 2022 Jan 4. PubMed |
Sequestration of TDP-43(216-414) Aggregates by Cytoplasmic Expression of the proSAAS Chaperone.
Peinado JR, Chaplot K, Jarvela TS, Barbieri EM, Shorter J, Lindberg I.
ACS Chem Neurosci. 2022 Jun 1;13(11):1651-1665. doi: 10.1021/acschemneuro.2c00156. Epub 2022 May 12.
PubMed
Associated Plasmids |
| Reduction of phosphorylated alpha-synuclein through downregulation of casein kinase 2alpha alleviates dopaminergic-neuronal function. Potdar C, Kaushal A, Raj A, Mallick R, Datta I. Biochem Biophys Res Commun. 2022 Jul 30;615:43-48. doi: 10.1016/j.bbrc.2022.05.023. Epub 2022 May 11. PubMed |
| Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance. Wrobel L, Hill SM, Djajadikerta A, Fernandez-Estevez M, Karabiyik C, Ashkenazi A, Barratt VJ, Stamatakou E, Gunnarsson A, Rasmusson T, Miele EW, Beaton N, Bruderer R, Feng Y, Reiter L, Castaldi MP, Jarvis R, Tan K, Burli RW, Rubinsztein DC. Nat Commun. 2022 Jul 16;13(1):4146. doi: 10.1038/s41467-022-31905-0. PubMed |
| Retrograde Axonal Autophagy and Endocytic Pathways Are Parallel and Separate in Neurons. Kulkarni VV, Stempel MH, Anand A, Sidibe DK, Maday S. J Neurosci. 2022 Nov 9;42(45):8524-8541. doi: 10.1523/JNEUROSCI.1292-22.2022. Epub 2022 Sep 27. PubMed |
| O-Cyclic Phytosphingosine-1-Phosphate Protects against Motor Dysfunctions and Glial Cell Mediated Neuroinflammation in the Parkinson's Disease Mouse Models. Lee HJ, Choe K, Park JS, Khan A, Kim MW, Park TJ, Kim MO. Antioxidants (Basel). 2022 Oct 26;11(11):2107. doi: 10.3390/antiox11112107. PubMed |
| The SATB1-MIR22-GBA axis mediates glucocerebroside accumulation inducing a cellular senescence-like phenotype in dopaminergic neurons. Russo T, Kolisnyk B, Bs A, Kim TW, Martin J, Plessis-Belair J, Ni J, Pearson JA, Park EJ, Sher RB, Studer L, Riessland M. bioRxiv. 2023 Jul 21:2023.07.19.549710. doi: 10.1101/2023.07.19.549710. Preprint. PubMed |
| Neuroprotective effects of osmotin in Parkinson's disease-associated pathology via the AdipoR1/MAPK/AMPK/mTOR signaling pathways. Park JS, Choe K, Lee HJ, Park TJ, Kim MO. J Biomed Sci. 2023 Aug 11;30(1):66. doi: 10.1186/s12929-023-00961-z. PubMed |
| The SATB1-MIR22-GBA axis mediates glucocerebroside accumulation inducing a cellular senescence-like phenotype in dopaminergic neurons. Russo T, Kolisnyk B, B S A, Plessis-Belair J, Kim TW, Martin J, Ni J, Pearson JA, Park EJ, Sher RB, Studer L, Riessland M. Aging Cell. 2024 Apr;23(4):e14077. doi: 10.1111/acel.14077. Epub 2024 Feb 1. PubMed |
| ANKZF1 helps to eliminate stress-damaged mitochondria by LC3-mediated mitophagy. Ali M, Anjali, Mapa K. Cell Death Discov. 2025 Jul 29;11(1):349. doi: 10.1038/s41420-025-02638-y. PubMed |
| Integrating artificial intelligence and optogenetics for Parkinson's disease diagnosis and therapeutics in male mice. Hyeon B, Shin J, Lee JH, Kim W, Kwon J, Lee H, Kim DG, Kim CY, Choi S, Jeong JW, Kim KS, Lee CJ, Kim D, Heo WD. Nat Commun. 2025 Aug 21;16(1):7797. doi: 10.1038/s41467-025-63025-w. PubMed |
| Gangliosides modulate the secretion of extracellular vesicles and their misfolded protein cargo. Monyror J, Kadam V, Morales LC, Ordonez D, Ibanga J, Zaidi AK, McNamara E, Pink D, Stenlund M, Reyes K, Maguire AD, Huang J, Cortez LM, Sim VL, Mok SA, Posse de Chaves E, Sipione S. Sci Adv. 2025 Sep 19;11(38):eady5212. doi: 10.1126/sciadv.ady5212. Epub 2025 Sep 17. PubMed |
| Skin-derived alpha-synuclein strains from PD, DLB, and MSA induce distinct intracellular pathology and neurodegeneration. Raina A, Wang W, Gonzalez JC, Yan X, Overstreet-Wadiche L, Wadiche JI, Zhang CL, Chen SG. J Biol Chem. 2026 Jan;302(1):111005. doi: 10.1016/j.jbc.2025.111005. Epub 2025 Dec 8. PubMed |
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