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Originally described in: Global protein stability profiling in mammalian cells.
Yen HC, Xu Q, Chou DM, Zhao Z, Elledge SJ Science. 2008 Nov 7;322(5903):918-23. doi: 10.1126/science.1160489.
PubMed Journal


Proteasomal Degradation of the EWS-FLI1 Fusion Protein Is Regulated by a Single Lysine Residue. Gierisch ME, Pfistner F, Lopez-Garcia LA, Harder L, Schafer BW, Niggli FK. J Biol Chem. 2016 Dec 23;291(52):26922-26933. doi: 10.1074/jbc.M116.752063. Epub 2016 Nov 8. PubMed
Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing. Thrun A, Garzia A, Kigoshi-Tansho Y, Patil PR, Umbaugh CS, Dallinger T, Liu J, Kreger S, Patrizi A, Cox GA, Tuschl T, Joazeiro CAP. Mol Cell. 2021 May 20;81(10):2112-2122.e7. doi: 10.1016/j.molcel.2021.03.004. Epub 2021 Apr 27. PubMed
Systematic Discovery of FBXW7-Binding Phosphodegrons Highlights Mitogen-Activated Protein Kinases as Important Regulators of Intracellular Protein Levels. Singh N, Zeke A, Remenyi A. Int J Mol Sci. 2022 Mar 19;23(6). pii: ijms23063320. doi: 10.3390/ijms23063320. PubMed

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