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pdCas9-Tet1-CD Citations (6)

Originally described in: A CRISPR-based approach for targeted DNA demethylation.
Xu X, Tao Y, Gao X, Zhang L, Li X, Zou W, Ruan K, Wang F, Xu GL, Hu R Cell Discov. 2016 May 3;2:16009. doi: 10.1038/celldisc.2016.9. eCollection 2016.
PubMed Journal

Articles Citing pdCas9-Tet1-CD

Enhanced CRISPR-based DNA demethylation by Casilio-ME-mediated RNA-guided coupling of methylcytosine oxidation and DNA repair pathways. Taghbalout A, Du M, Jillette N, Rosikiewicz W, Rath A, Heinen CD, Li S, Cheng AW. Nat Commun. 2019 Sep 20;10(1):4296. doi: 10.1038/s41467-019-12339-7. PubMed

Associated Plasmids

Epigenetic therapy of novel tumour suppressor ZAR1 and its cancer biomarker function. Deutschmeyer V, Breuer J, Walesch SK, Sokol AM, Graumann J, Bartkuhn M, Boettger T, Rossbach O, Richter AM. Clin Epigenetics. 2019 Dec 4;11(1):182. doi: 10.1186/s13148-019-0774-2. PubMed
A methylation functional detection hepatic cell system validates correlation between DNA methylation and drug-induced liver injury. Wei Y, Huai C, Zhou C, Gao Y, Chen L, Zhou W, Wei M, Qin S. Pharmacogenomics J. 2020 Feb 7. pii: 10.1038/s41397-020-0160-7. doi: 10.1038/s41397-020-0160-7. PubMed
CRISPR/Cas9-mediated demethylation of FOXP3-TSDR toward Treg-characteristic programming of Jurkat T cells. Wilk C, Effenberg L, Abberger H, Steenpass L, Hansen W, Zeschnigk M, Kirschning C, Buer J, Kehrmann J. Cell Immunol. 2022 Jan;371:104471. doi: 10.1016/j.cellimm.2021.104471. Epub 2021 Dec 20. PubMed
Targeted demethylation at ZNF154 promotor upregulates ZNF154 expression and inhibits the proliferation and migration of Esophageal Squamous Carcinoma cells. He W, Lin S, Guo Y, Wu Y, Zhang LL, Deng Q, Du ZM, Wei M, Zhu W, Chen WJ, Shao JY, Xu GL. Oncogene. 2022 Sep;41(40):4537-4546. doi: 10.1038/s41388-022-02366-y. Epub 2022 Sep 5. PubMed
Epigenetic reactivation of tumor suppressor genes with CRISPRa technologies as precision therapy for hepatocellular carcinoma. Sgro A, Cursons J, Waryah C, Woodward EA, Foroutan M, Lyu R, Yeoh GCT, Leedman PJ, Blancafort P. Clin Epigenetics. 2023 Apr 29;15(1):73. doi: 10.1186/s13148-023-01482-0. PubMed

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