Skip to main content
This website uses cookies to ensure you get the best experience. By continuing to use this site, you agree to the use of cookies.

Please note: Your browser does not support the features used on Addgene's website. You may not be able to create an account or request plasmids through this website until you upgrade your browser. Learn more

Please note: Your browser does not fully support some of the features used on Addgene's website. If you run into any problems registering, depositing, or ordering please contact us at [email protected] Learn more

pcDNA3-FLAG-LKB1 Citations (15)

Plasmid Article: The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.
Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC Proc Natl Acad Sci U S A 2004 Mar 9;101(10):3329-35. Epub 2004 Feb 25.
PubMed Journal

Articles Citing pcDNA3-FLAG-LKB1

Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart. Morrison A, Chen L, Wang J, Zhang M, Yang H, Ma Y, Budanov A, Lee JH, Karin M, Li J. FASEB J. 2015 Feb;29(2):408-17. doi: 10.1096/fj.14-258814. Epub 2014 Nov 3. PubMed
A Critical SUMO1 Modification of LKB1 Regulates AMPK Activity during Energy Stress. Ritho J, Arold ST, Yeh ET. Cell Rep. 2015 Aug 4;12(5):734-42. doi: 10.1016/j.celrep.2015.07.002. Epub 2015 Jul 23. PubMed
Regulation of triple-negative breast cancer cell metastasis by the tumor-suppressor liver kinase B1. Rhodes LV, Tate CR, Hoang VT, Burks HE, Gilliam D, Martin EC, Elliott S, Miller DB, Buechlein A, Rusch D, Tang H, Nephew KP, Burow ME, Collins-Burow BM. Oncogenesis. 2015 Oct 5;4:e168. doi: 10.1038/oncsis.2015.27. PubMed
Lysosomal recruitment of TSC2 is a universal response to cellular stress. Demetriades C, Plescher M, Teleman AA. Nat Commun. 2016 Feb 12;7:10662. doi: 10.1038/ncomms10662. PubMed
A Sensitive NanoString-Based Assay to Score STK11 (LKB1) Pathway Disruption in Lung Adenocarcinoma. Chen L, Engel BE, Welsh EA, Yoder SJ, Brantley SG, Chen DT, Beg AA, Cao C, Kaye FJ, Haura EB, Schabath MB, Cress WD. J Thorac Oncol. 2016 Jun;11(6):838-49. doi: 10.1016/j.jtho.2016.02.009. Epub 2016 Feb 23. PubMed
Focal Adhesion Kinase Inhibitors in Combination with Erlotinib Demonstrate Enhanced Anti-Tumor Activity in Non-Small Cell Lung Cancer. Howe GA, Xiao B, Zhao H, Al-Zahrani KN, Hasim MS, Villeneuve J, Sekhon HS, Goss GD, Sabourin LA, Dimitroulakos J, Addison CL. PLoS One. 2016 Mar 10;11(3):e0150567. doi: 10.1371/journal.pone.0150567. eCollection 2016. PubMed
Mitochondrial biogenesis is required for axonal growth. Vaarmann A, Mandel M, Zeb A, Wareski P, Liiv J, Kuum M, Antsov E, Liiv M, Cagalinec M, Choubey V, Kaasik A. Development. 2016 Jun 1;143(11):1981-92. doi: 10.1242/dev.128926. Epub 2016 Apr 27. PubMed
Metformin Induces Osteoblastic Differentiation of Human Induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells. Wang P, Ma T, Guo D, Hu K, Shu Y, Xu HHK, Schneider A. J Tissue Eng Regen Med. 2017 May 11. doi: 10.1002/term.2470. PubMed
Aurora-A-mediated phosphorylation of LKB1 compromises LKB1/AMPK signaling axis to facilitate NSCLC growth and migration. Zheng X, Chi J, Zhi J, Zhang H, Yue D, Zhao J, Li D, Li Y, Gao M, Guo J. Oncogene. 2018 Jan 25;37(4):502-511. doi: 10.1038/onc.2017.354. Epub 2017 Oct 2. PubMed
Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation. O'Farrell F, Lobert VH, Sneeggen M, Jain A, Katheder NS, Wenzel EM, Schultz SW, Tan KW, Brech A, Stenmark H, Rusten TE. Nat Cell Biol. 2017 Dec;19(12):1412-1423. doi: 10.1038/ncb3631. Epub 2017 Oct 30. PubMed
Liver kinase B1 restoration promotes exosome secretion and motility of lung cancer cells. Zhang C, Xiao X, Chen M, Aldharee H, Chen Y, Long W. Oncol Rep. 2018 Jan;39(1):376-382. doi: 10.3892/or.2017.6085. Epub 2017 Nov 9. PubMed
The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer. Jin L, Chun J, Pan C, Kumar A, Zhang G, Ha Y, Li D, Alesi GN, Kang Y, Zhou L, Yu WM, Magliocca KR, Khuri FR, Qu CK, Metallo C, Owonikoko TK, Kang S. Mol Cell. 2018 Jan 4;69(1):87-99.e7. doi: 10.1016/j.molcel.2017.11.025. Epub 2017 Dec 14. PubMed
LKB1, Salt-Inducible Kinases, and MEF2C Are Linked Dependencies in Acute Myeloid Leukemia. Tarumoto Y, Lu B, Somerville TDD, Huang YH, Milazzo JP, Wu XS, Klingbeil O, El Demerdash O, Shi J, Vakoc CR. Mol Cell. 2018 Feb 28. pii: S1097-2765(18)30109-6. doi: 10.1016/j.molcel.2018.02.011. PubMed

Associated Plasmids

Concurrent regulation of LKB1 and CaMKK2 in the activation of AMPK in castrate-resistant prostate cancer by a well-defined polyherbal mixture with anticancer properties. MacDonald AF, Bettaieb A, Donohoe DR, Alani DS, Han A, Zhao Y, Whelan J. BMC Complement Altern Med. 2018 Jun 18;18(1):188. doi: 10.1186/s12906-018-2255-0. PubMed
Hyaluronidase2 (Hyal2) modulates low shear stress-induced glycocalyx impairment via the LKB1/AMPK/NADPH oxidase-dependent pathway. Yang H, Zhu L, Chao Y, Gu Y, Kong X, Chen M, Ye P, Luo J, Chen S. J Cell Physiol. 2018 Dec;233(12):9701-9715. doi: 10.1002/jcp.26944. Epub 2018 Aug 5. PubMed

If you have published an article using this plasmid, please email us at [email protected] to have your article added to this page.