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The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.
Tsun ZY, Bar-Peled L, Chantranupong L, Zoncu R, Wang T, Kim C, Spooner E, Sabatini DM
Mol Cell. 2013 Nov 21;52(4):495-505. doi: 10.1016/j.molcel.2013.09.016. Epub 2013 Oct 3. PubMed Article

Plasmids from Article

ID Plasmid Purpose
72289FLCN-eGFPExpresses human FLCN tagged with eGFP at C terminus
72290pRK5-FLAG-FLCNoverexpression
72291pRK5-HA-FLCNoverexpression
72292pRK5-FLAG-FNIP1overexpression
72293pRK5-HA-FNIP1overexpression
72294pRK5-FLAG-FNIP2overexpression
72295pRK5-HA-FNIP2overexpression
72296pRK5-FLAG-FLCN (C terminus)overexpression
72297pRK5-HA-FLCN (C terminus)overexpression

Antibodies from Article