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Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT.
Leszczynska KB, Foskolou IP, Abraham AG, Anbalagan S, Tellier C, Haider S, Span PN, O'Neill EE, Buffa FM, Hammond EM
J Clin Invest. 2015 Jun;125(6):2385-98. doi: 10.1172/JCI80402. Epub 2015 May 11. PubMed Article

Plasmids from Article

ID Plasmid Purpose
72554pGLS3-5xHRE-p53(K120R)Hypoxia induced mutant p53. Contains the HRE from VEGF sequence (5 repeats) upstream of p53 K120R.
72555pGLS3-5xHRE-p53(K164R)Hypoxia induced mutant p53. Contains the HRE from VEGF sequence (5 repeats) upstream of p53 K164R.
72556pGLS3-5xHRE-p53(K120R/K164R)Hypoxia induced mutant p53. Contains the HRE from VEGF sequence (5 repeats) upstream of p53 K120R/K164R.
72557pGLS3-5xHRE-PHLDA3(wt)Hypoxia induced mutant PHLDA3. Contains the HRE from VEGF sequence (5 repeats) upstream of PHLDA3.

Antibodies from Article