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Addgene
XPLN is an endogenous inhibitor of mTORC2.
Khanna N, Fang Y, Yoon MS, Chen J
Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):15979-84. doi: 10.1073/pnas.1310434110. Epub 2013 Sep 16. PubMed Article

Plasmids from Article

ID Plasmid Purpose
73376pCMV-Myc-XPLN-L269EMammalian expression of mutant XPLN (Arhgef3) gene Leu269 --> Glu
73377pCMV-Myc-XPLN-W440LMyc tagged human XPLN expression with a point mutation W440L
73378pCMV-Myc-XPLN aa1-125 (N125)Expression of the N-terminal region of XPLN (amino acids 1–125, designated N125)
73379pCMV-Myc-XPLN aa107-311Expresses amino acids 107-317 of XPLN (Arhgef3) protein
73380pCMV-Myc-XPLN aa304-466 (PH)Expresses amino acids 304-466 of XPLN (Arhgef3) protein
73381pCMV-Myc-XPLN aa452-526Expresses amino acids 452-526 of XPLN (Arhgef3) protein
73382pCMV-Myc-XPLN (delta)N (aa1-117 deleted)Expresses myc tagged XPLN in mammalian cells with deletion of N-terminal amino acids 1-117

Antibodies from Article