Sestrin2 is a leucine sensor for the mTORC1 pathway.
Wolfson RL, Chantranupong L, Saxton RA, Shen K, Scaria SM, Cantor JR, Sabatini DM
Science. 2016 Jan 1;351(6268):43-8. doi: 10.1126/science.aab2674. Epub 2015 Oct 8. PubMed Article
Wolfson RL, Chantranupong L, Saxton RA, Shen K, Scaria SM, Cantor JR, Sabatini DM
Science. 2016 Jan 1;351(6268):43-8. doi: 10.1126/science.aab2674. Epub 2015 Oct 8. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 73670 | pRK5-FLAG-Sestrin2-S190W | overexpression |
| 73671 | pRK5-FLAG-Sestrin2-L261A | overexpression |
| 73672 | pRK5-HA-Sestrin2-L261A | overexpression |
| 73673 | pRK5-FLAG-Sestrin2-E451A | overexpression |
| 73674 | pRK5-HA-Sestrin2-E451A | overexpression |
| 73675 | pRK5-FLAG-dSestrin (CG11299-PD) | overexpression |
| 73676 | pLJM1-FLAG-Sestrin2-L261A | overexpression |
| 73677 | pLJM1-FLAG-Sestrin2-E451A | overexpression |
| 73678 | pS2-FLAG-Sestrin2-L261A | overexpression |
| 73679 | pS2-FLAG-Sestrin2-E451A | overexpression |