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Methyl-CpG binding domain protein 1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner.

Zhang P, Rausch C, Hastert FD, Boneva B, Filatova A, Patil SJ, Nuber UA, Gao Y, Zhao X, Cardoso MC
Nucleic Acids Res. 2017 Apr 25. doi: 10.1093/nar/gkx281. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
167563pENeCFPCNAL2 pc922For construction of CFP-tagged human PCNA, the GFP coding sequence in the pENeGFPCNAL2 vector was replaced by the ECFP coding sequence from the pECFP-C1 vector (Clontech Laboratories, Inc., CA).
246848pCAG-RFP-mouse Tet1 (pc2329)Expresses mRFP tagged mouse Tet1 in mammalian cells. N-terminal tagged to mCherry.
246849pmMBD1.2G (pc2845)Mammalian expression plasmid of mouse MBD1 N-terminus (aa396-636). C-terminal tagged to GFP.
246850pmGMBD1.3(pc2899)Mammalian expression plasmid of mouse MBD1 lacking the CXXC3 domain. N-terminal tagged to GFP.
246851pGmMBD1.4 (pc3305)Mammalian expression plasmid of mouse MBD1 lacking the MBD domain (aa 75–636). N-terminal tagged to GFP.
246852pGmMBD1.5 (pc3306)Mammalian expression plasmid of MBD domain and NLS of mouse MBD1. N-terminal tagged to GFP.
246862pCAG-mch-Tet2CD (pc3338)Expresses mCherry-tagged catalytic active domain of mouse Tet2 in mammalian cells. N-terminal tagged to mCherry.
246869pCAG-mch-Tet3CD (pc3339)Expresses mCherry-tagged catalytic active domain of mouse Tet3 in mammalian cells. N-terminal tagged to mCherry.
246870pmMBD1.7G (pc3343)Mammalian expression plasmid of full length MBD1 with pointmutations C289 and 292A. C-terminal tagged to GFP

Antibodies from Article