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Transmission of innate immune signaling by packaging of cGAMP in viral particles.
Gentili M, Kowal J, Tkach M, Satoh T, Lahaye X, Conrad C, Boyron M, Lombard B, Durand S, Kroemer G, Loew D, Dalod M, Thery C, Manel N
Science. 2015 Sep 11;349(6253):1232-6. doi: 10.1126/science.aab3628. Epub 2015 Jul 30.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
102597IFN-Beta_pGL3IFN-beta promoter driving luciferase. Use in IFN reporter assay.
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102602pTRIP-CMV-mTagBFP2-2AControl lentivector. Coexpression of mTagBFP and gene of interest from CMV promoter
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102603pTRIP-CMV-mTagBFP2-2A-FLAG-ntcGASLentivector to express Flag-tagged and shRNA-resistant cGAS and mTagBFP
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102604pTRIP-CMV-mtagBFP2-2A-FLAG-cGAS E225A/D227ALentivector to express Flag-tagged and catalytically-inactive cGAS and mTagBFP
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102605pcDNA3.1-Hygro(+)-PSTCD-cGASMammalian expression of cGAS fused to PSTCD tag
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102606pcDNA3.1-Hygro(+)-PSTCD-cGAS-delta DBDMammalian expression of mutant cGAS with deletion of DNA binding domain fused to PSTCD tag
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102607pcDNA3.1-Hygro(+)-mscGASMammalian expression of mouse cGAS
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102608pMSCV-hygro-STING R232Retroviral vector to expression STING R232
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102609pLCRISPR-CMVControl lentivector expressing Cas9 and gRNA scaffold
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102610pLCRISPR-CMV-cGAS3CRISPR/Cas9 lentivector targeting human cGAS
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102611pTRIP-CMV-Puro-2AControl lentivector expressing Puro resistance and gene of interest from CMV promoter
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102612pTRIP-CMV-Puro-2A-cGASLentivector expressing cGAS
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Antibodies from Article