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In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation.
Liao HK, Hatanaka F, Araoka T, Reddy P, Wu MZ, Sui Y, Yamauchi T, Sakurai M, O'Keefe DD, Nunez-Delicado E, Guillen P, Campistol JM, Wu CJ, Lu LF, Esteban CR, Izpisua Belmonte JC
Cell. 2017 Dec 14;171(7):1495-1507.e15. doi: 10.1016/j.cell.2017.10.025. Epub 2017 Dec 7.
PubMed Article

Plasmids from Article

ID Plasmid Purpose
106259AAV-U6-dgRNA-CAG-MPHExpresses MPH co-activator from the CAG promoter and one U6-driven dgRNA in AAV backbone
106430AAV-nEF-dCas9Expresses SpdCas9 from the nEF promoter in AAV backbone
106431AAV-CMVc-Cas9Expresses SpCas9 from the CMVc promoter in AAV backbone
107552AAV-tLuctLuc in AAV backbone
107553AAV-tLuc-mCherrytLuc-mCherry in AAV backbone

Antibodies from Article