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Oncogenic K-Ras upregulates ITGA6 expression via FOSL1 to induce anoikis resistance and synergizes with alphaV-Class integrins to promote EMT.
Zhang K, Myllymaki SM, Gao P, Devarajan R, Kytola V, Nykter M, Wei GH, Manninen A
Oncogene. 2017 Oct 12;36(41):5681-5694. doi: 10.1038/onc.2017.177. Epub 2017 Jun 12.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
107139pLVET-IRES-GFP A bicistronic lentiviral mammalian expression vector with a multiple cloning site and GFP
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107140pLVET-HA-K-RasG12V-IRES-GFPA bicistronic lentiviral mammalian expression vector for HA-KRasG12V(4B) and GFP
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107141pGL3-ITGA6-1k-Basic-LUCLuciferase reporter plasmid to monitor transcriptional activity of canine ITGA6-promoter (1kb fragment)
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