Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation.
Pircs K, Petri R, Madsen S, Brattas PL, Vuono R, Ottosson DR, St-Amour I, Hersbach BA, Matusiak-Bruckner M, Lundh SH, Petersen A, Deglon N, Hebert SS, Parmar M, Barker RA, Jakobsson J
Cell Rep. 2018 Aug 7;24(6):1397-1406. doi: 10.1016/j.celrep.2018.07.017. PubMed Article
Pircs K, Petri R, Madsen S, Brattas PL, Vuono R, Ottosson DR, St-Amour I, Hersbach BA, Matusiak-Bruckner M, Lundh SH, Petersen A, Deglon N, Hebert SS, Parmar M, Barker RA, Jakobsson J
Cell Rep. 2018 Aug 7;24(6):1397-1406. doi: 10.1016/j.celrep.2018.07.017. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 107934 | pAAV-hSyn-Htt171-66Q-myc-WPRE | Adeno-Associated viral (AAV) vector plasmid expressing exon1 of mutant HTT (mHTT, 66 polyQ repeats) in neurons |
| 107936 | pAAV-hSyn-Htt171-18Q-myc-WPRE | Adeno-Associated viral (AAV) vector plasmid expressing exon1 of wild type HTT (wtHTT, 18 polyQ repeats) in neurons |
| 107937 | pAAV2-SBECN1W | Adeno-Associated viral (AAV) vector plasmid expressing mouse Beclin-1 (BECN1) in neurons |