Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces.
Warszawski S, Borenstein Katz A, Lipsh R, Khmelnitsky L, Ben Nissan G, Javitt G, Dym O, Unger T, Knop O, Albeck S, Diskin R, Fass D, Sharon M, Fleishman SJ
PLoS Comput Biol. 2019 Aug 23;15(8):e1007207. doi: 10.1371/journal.pcbi.1007207. eCollection 2019 Aug. PubMed Article
Warszawski S, Borenstein Katz A, Lipsh R, Khmelnitsky L, Ben Nissan G, Javitt G, Dym O, Unger T, Knop O, Albeck S, Diskin R, Fass D, Sharon M, Fleishman SJ
PLoS Comput Biol. 2019 Aug 23;15(8):e1007207. doi: 10.1371/journal.pcbi.1007207. eCollection 2019 Aug. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 110212 | Designed VEGF-binding scFv G6des1 | Yeast Surface Display of G6des1 |
| 110213 | Designed VEGF-binding scFv G6des13 | Yeast Surface Display of G6des13 |
| 111716 | VEGF binding scFv G6 | Yeast Surface Display of G6 as a reference starting point for design |
| 111718 | HEL binding scFv D44.1 | Yeast Surface Display of D44.1 as a reference starting point for design |
| 111719 | Designed HEL-binding scFv D44.1des | Yeast Surface Display of D44.1des |