BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis.
McArthur K, Whitehead LW, Heddleston JM, Li L, Padman BS, Oorschot V, Geoghegan ND, Chappaz S, Davidson S, San Chin H, Lane RM, Dramicanin M, Saunders TL, Sugiana C, Lessene R, Osellame LD, Chew TL, Dewson G, Lazarou M, Ramm G, Lessene G, Ryan MT, Rogers KL, van Delft MF, Kile BT
Science. 2018 Feb 23;359(6378). pii: 359/6378/eaao6047. doi: 10.1126/science.aao6047. PubMed Article
McArthur K, Whitehead LW, Heddleston JM, Li L, Padman BS, Oorschot V, Geoghegan ND, Chappaz S, Davidson S, San Chin H, Lane RM, Dramicanin M, Saunders TL, Sugiana C, Lessene R, Osellame LD, Chew TL, Dewson G, Lazarou M, Ramm G, Lessene G, Ryan MT, Rogers KL, van Delft MF, Kile BT
Science. 2018 Feb 23;359(6378). pii: 359/6378/eaao6047. doi: 10.1126/science.aao6047. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 111626 | pMIH-TOMM20-Halo | Fusion protein used to visualise mitochondria upon the addition of Halo specific dye, has hygromycin selection |
| 111627 | pMIH-mRuby2-BAK | Fluorescent fusion protein used to visualise mouse BAK, with hygromycin selection |
| 111628 | pMIH-mRuby2-BAX | Fluorescent fusion protein used to visualise mouse BAX, with hygromycin selection |
| 113704 | pMIH-TFAM-GFP | Fluorescent fusion protein used to visualise mitochondrial nucleoids, with hygromycin selection |