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METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m(6)A Modification.

Weng H, Huang H, Wu H, Qin X, Zhao BS, Dong L, Shi H, Skibbe J, Shen C, Hu C, Sheng Y, Wang Y, Wunderlich M, Zhang B, Dore LC, Su R, Deng X, Ferchen K, Li C, Sun M, Lu Z, Jiang X, Marcucci G, Mulloy JC, Yang J, Qian Z, Wei M, He C, Chen J
Cell Stem Cell. 2018 Feb 1;22(2):191-205.e9. doi: 10.1016/j.stem.2017.11.016. Epub 2017 Dec 28. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
141112pCDH-METTL14-WTOverexpression of WT METTL14 in mammalian cells.
141113PCDH-METTL14-R298POverexpression of METTL14 mutant in mammalian cells.
141114pmiR-report-MYB-WTReporter plasmid of WT MYB in mammalian cells.
141115pmiR-report-MYB-mutReporter plasmid of mutant MYB in mammalian cells.
141118MSCV-PIG-METTL14-WTRetroviral overexpression of WT METTL14 in mammalian cells.
141119MSCV-PIG-METTL14-R298PRetroviral overexpression of mutant METTL14 in mammalian cells.
141120pmiRA1-MYBLentiviral overexpression of MYB in mammalian cells.
141121pmiRA1-MYCLentiviral overexpression of MYC in mammalian cells.

Antibodies from Article