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Locus-specific DNA methylation of Mecp2 promoter leads to autism-like phenotypes in mice.
Lu Z, Liu Z, Mao W, Wang X, Zheng X, Chen S, Cao B, Huang S, Zhang X, Zhou T, Zhang Y, Huang X, Sun Q, Li JD
Cell Death Dis. 2020 Feb 3;11(2):85. doi: 10.1038/s41419-020-2290-x.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
112209pSt1374-N-NLS-DNMT3L-L-DNMT3Amut-L-dcas9-NLSTargeted DNA methylation
112210pSt1374-N-NLS-DNMT3L-L-DNMT3A-L-dcas9-NLSTargeted DNA methylation
112211pAAV-CAG-C-intein-C-spC9-H840A-N863A-2xNLS-hGHTargeted DNA methylation
112212pAAV-CAG-NLS-DNMT3A-L-N-spC9-N-intein-hGHTargeted DNA methylation
112213pAAV-5U6-sgRNAs-hsyn-EGFPTargeted DNA methylation
112214pSt1374m-EF1alpha-N-NLS-DNMT3L-L-DNMT3A-L-dcas9-NLSTargeted DNA methylation
112215pSt1374m-EF1alpha-N-NLS-DNMT3L-L-DNMT3Amut-L-dcas9-NLSTargeted DNA methylation