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Locus-specific DNA methylation of Mecp2 promoter leads to autism-like phenotypes in mice.
Lu Z, Liu Z, Mao W, Wang X, Zheng X, Chen S, Cao B, Huang S, Zhang X, Zhou T, Zhang Y, Huang X, Sun Q, Li JD
Cell Death Dis. 2020 Feb 3;11(2):85. doi: 10.1038/s41419-020-2290-x.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
112209pSt1374-N-NLS-DNMT3L-L-DNMT3Amut-L-dcas9-NLSTargeted DNA methylation
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112210pSt1374-N-NLS-DNMT3L-L-DNMT3A-L-dcas9-NLSTargeted DNA methylation
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112211pAAV-CAG-C-intein-C-spC9-H840A-N863A-2xNLS-hGHTargeted DNA methylation
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112212pAAV-CAG-NLS-DNMT3A-L-N-spC9-N-intein-hGHTargeted DNA methylation
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112213pAAV-5U6-sgRNAs-hsyn-EGFPTargeted DNA methylation
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112214pSt1374m-EF1alpha-N-NLS-DNMT3L-L-DNMT3A-L-dcas9-NLSTargeted DNA methylation
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112215pSt1374m-EF1alpha-N-NLS-DNMT3L-L-DNMT3Amut-L-dcas9-NLSTargeted DNA methylation
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