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Autoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombination.
Grundy GJ, Yang W, Gellert M
Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22487-92. doi: 10.1073/pnas.1014958107. Epub 2010 Dec 13.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
115646coreR1 (384-1008)expression of truncated Rag1
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115647UR1Ct (265-1040)expression of truncated Rag1 including the RING, E3 ubiquitin ligase (265-1008) and C-terminal region (384-1040)
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115648coreR2 (1-387)expression of truncated Rag2
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115649R2Ct (1-520)expression of truncated Rag2 including the C-terminal region
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115650Rag2 T490Aexpression of full length Rag2 with T490A mutation
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Recombinant Antibodies from Article