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Tumor suppressor PNRC1 blocks rRNA maturation by recruiting the decapping complex to the nucleolus.
Gaviraghi M, Vivori C, Pareja Sanchez Y, Invernizzi F, Cattaneo A, Santoliquido BM, Frenquelli M, Segalla S, Bachi A, Doglioni C, Pelechano V, Cittaro D, Tonon G
EMBO J. 2018 Dec 3;37(23). pii: embj.201899179. doi: 10.15252/embj.201899179. Epub 2018 Oct 29.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
123292pEF-DEST51 LacZMammalian expression of control truncated LacZ
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123293pEF-DEST51 PNRC1Expression of PNRC1 in mammalian cells
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123294pEF-DEST51 HA-PNRC1Mammalian expression of PNRC1 N-HA
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123295pEF-DEST51 GFP-PNRC1Mammalian expression of PNRC1 N-GFP
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123297pLenti4 Blast RFP-PNRC1Mammalian expression of PNRC1 N-RFP
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123298pLenti4 Blast RFP-PNRC1 W300AMammalian expression of PNRC1-W300A mutant N-RFP
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123299pLenti c-MYC-DDK-Puro GFPMammalian expression of GFP C-MYC-FLAG
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123300pLenti C-MYC-DDK Puro PNRC1Mammalian expression of PNRC1 C-MYC-FLAG
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123301pLenti C-MYC-DDK Puro PNRC1-W300AMammalian expression of PNRC1-W300A mutant C-MYC-FLAG
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123306pLKO.1 Blast NT shRNAExpression of a non-targeting shRNA
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Antibodies from Article