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A high-throughput screening and computation platform for identifying synthetic promoters with enhanced cell-state specificity (SPECS).
Wu MR, Nissim L, Stupp D, Pery E, Binder-Nissim A, Weisinger K, Enghuus C, Palacios SR, Humphrey M, Zhang Z, Maria Novoa E, Kellis M, Weiss R, Rabkin SD, Tabach Y, Lu TK
Nat Commun. 2019 Jun 28;10(1):2880. doi: 10.1038/s41467-019-10912-8.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
127842SPECS libraryFor performing high-throughput cell state-specific synthetic promoter screening
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128569Accessory plasmid 1for mixing with SPECS library to produce lentivirus
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128571Accessory plasmid 2for cloning identified individual SPECS
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