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Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication.
Ardeljan D, Steranka JP, Liu C, Li Z, Taylor MS, Payer LM, Gorbounov M, Sarnecki JS, Deshpande V, Hruban RH, Boeke JD, Fenyo D, Wu PH, Smogorzewska A, Holland AJ, Burns KH
Nat Struct Mol Biol. 2020 Feb;27(2):168-178. doi: 10.1038/s41594-020-0372-1. Epub 2020 Feb 10.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
131380pDA007ORFeus expression, WT
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131384pDA025ORFeus expression, mutant
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131385pDA027ORFeus expression, mutant
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131386pDA034ORFeus expression, mutant
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131387pDA056ORFeus expression, WT
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131388pDA077L1RP expression
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131389pDA083eGFP expression
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131390pDA093generation of Tet-On RPE
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131391pDA095generation of Tet-On RPE
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131392pMT525L1RP retrotransposition reporter
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131452pDA019control expression vector
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Recombinant Antibodies from Article