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Weak membrane interactions allow Rheb to activate mTORC1 signaling without major lysosome enrichment.
Angarola B, Ferguson SM
Mol Biol Cell. 2019 Oct 15;30(22):2750-2760. doi: 10.1091/mbc.E19-03-0146. Epub 2019 Sep 18.
PubMed Article

Plasmids from Article

ID Plasmid Purpose
133766pEGFP-C1-RhebL1Expresses GFP-tagged RhebL1 in mammalian cells
133767pEGFP-C1-RhebExpresses GFP-tagged Rheb in mammalian cells
133768px459-Rheb sgRNAExpresses Cas9 and human Rheb sgRNA
133769px459-RhebL1 sgRNAExpresses Cas9 and human RhebL1 sgRNA

Antibodies from Article