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TAPBPR promotes antigen loading on MHC-I molecules using a peptide trap.
McShan AC, Devlin CA, Morozov GI, Overall SA, Moschidi D, Akella N, Procko E, Sgourakis NG
Nat Commun. 2021 May 26;12(1):3174. doi: 10.1038/s41467-021-23225-6.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
141308pCEP4-FLAG-TapasinMammalian expression of FLAG-tagged Tapasin
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141309pCEP4-FLAG-TAPBPR-tapasinCTMammalian expression of FLAG-tagged TAPBPR with tapasin CT
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153471pCEP4-FLAG-TAPBPR-tapasinCT deltaALASMammalian expression of FLAG-tagged TAPBPR with tapasin CT deltaALAS
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153472pCEP4-FLAG-TAPBPR-tapasinCT delta24-36Mammalian expression of FLAG-tagged TAPBPR with tapasin CT delta24-36
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153473pCEP4-FLAG-TAPBPR-tapasinCT E102AMammalian expression of FLAG-tagged TAPBPR with tapasin CT E102A
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153474pCEP4-FLAG-TAPBPR-tapasinCT M122AMammalian expression of FLAG-tagged TAPBPR with tapasin CT M122A
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153475pCEP4-FLAG-TAPBPR-tapasinCT G212AMammalian expression of FLAG-tagged TAPBPR with tapasin CT G212A
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153476pCEP4-FLAG-TAPBPR-tapasinCT I261AMammalian expression of FLAG-tagged TAPBPR with tapasin CT I261A
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153477pCEP4-FLAG-TAPBPR-tapasinCT S333AMammalian expression of FLAG-tagged TAPBPR with tapasin CT S333A
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153478pCEP4-FLAG-Tapasin-TAPBPR 22-35Mammalian expression of FLAG-tagged Tapasin with TAPBPR a.a. 22-35
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153479pCEP4-FLAG-Tapasin delta2stepMammalian expression of FLAG-tagged Tapasin delta2step
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153480pCEP4-FLAG-Tapasin delta3stepMammalian expression of FLAG-tagged Tapasin delta3step
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153481pCEP4-FLAG-Tapasin G15EMammalian expression of FLAG-tagged Tapasin G15E
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153482pCEP4-FLAG-Tapasin G15LMammalian expression of FLAG-tagged Tapasin G15L
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153483pCEP4-FLAG-Tapasin L18EMammalian expression of FLAG-tagged Tapasin L18E
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153484pCEP4-FLAG-Tapasin L18GMammalian expression of FLAG-tagged Tapasin L18G
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153485pCEP4-FLAG-Tapasin L18KMammalian expression of FLAG-tagged Tapasin L18K
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153486pETCON-Aga2p-TAPBPR-mycYeast expression of Aga2p-TAPBPR-myc
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Antibodies from Article