Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.
Lawson KA, Sousa CM, Zhang X, Kim E, Akthar R, Caumanns JJ, Yao Y, Mikolajewicz N, Ross C, Brown KR, Zid AA, Fan ZP, Hui S, Krall JA, Simons DM, Slater CJ, De Jesus V, Tang L, Singh R, Goldford JE, Martin S, Huang Q, Francis EA, Habsid A, Climie R, Tieu D, Wei J, Li R, Tong AHY, Aregger M, Chan KS, Han H, Wang X, Mero P, Brumell JH, Finelli A, Ailles L, Bader G, Smolen GA, Kingsbury GA, Hart T, Kung C, Moffat J
Nature. 2020 Oct;586(7827):120-126. doi: 10.1038/s41586-020-2746-2. Epub 2020 Sep 23.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 159391 | Mouse Validation (mVAL) CRISPR Library | Targets 182 immune evasion genes. Designed for loss-of-function screening against genes shown to increase sensistivity or resistance of cancer cells to cytotoxic T lymphocyte-mediated toxicity. |
| 159392 | Mouse Toronto KnockOut (mTKO) CRISPR Library - lentiCRISPRv2 | Mouse lentiviral genome-wide CRISPR library |
| 159393 | Mouse Toronto KnockOut (mTKO) CRISPR Library - pLCKO2 | Mouse lentiviral genome-wide CRISPR library |