An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction.
Hanke L, Vidakovics Perez L, Sheward DJ, Das H, Schulte T, Moliner-Morro A, Corcoran M, Achour A, Karlsson Hedestam GB, Hallberg BM, Murrell B, McInerney GM
Nat Commun. 2020 Sep 4;11(1):4420. doi: 10.1038/s41467-020-18174-5. PubMed Article
Hanke L, Vidakovics Perez L, Sheward DJ, Das H, Schulte T, Moliner-Morro A, Corcoran M, Achour A, Karlsson Hedestam GB, Hallberg BM, Murrell B, McInerney GM
Nat Commun. 2020 Sep 4;11(1):4420. doi: 10.1038/s41467-020-18174-5. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 194588 | pHEN-CoV2-nanobody-Ty1 | Bacterial expression of Ty1 nanobody targeting the receptor binding domain (RBD) of SARS-CoV-2 spike |
| 194593 | hIgG1-Ty1-hFc | Mammalian expression of Ty1 nanobody upstream of human IgG1 |