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Molecular features underlying differential SHP1/SHP2 binding of immune checkpoint receptors.
Xu X, Masubuchi T, Cai Q, Zhao Y, Hui E
Elife. 2021 Nov 4;10. pii: 74276. doi: 10.7554/eLife.74276. PubMed Article

Plasmids from Article

ID Plasmid Purpose
180817pHR-PD-1 (BTLA ITIM)-mGFPExpression of human PD-1 (BTLA ITIM) fused to mGFP
180818pHR-BTLA (PD-1 ITIM)-mGFPExpression of human BTLA (PD-1 ITIM) fused to mGFP
180819pHR-PD-1 G224A-mGFPExpression of human PD-1 G224A fused to mGFP
180822pHR-SV40-mCherry-SHP1 (SHP2-cSH2)Expression of N-terminal mCherry tagged human SHP1 with its cSH2 replaced by SHP2-cSH2
180823pHR-SV40-mCherry-SHP1 (SHP2-nSH2, cSH2)Expression of N-terminal mCherry tagged human SHP1 with its nSH2 and cSH2 replaced by nSH2 and cSH2 of SHP2

Antibodies from Article