DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer.
Mao C, Liu X, Zhang Y, Lei G, Yan Y, Lee H, Koppula P, Wu S, Zhuang L, Fang B, Poyurovsky MV, Olszewski K, Gan B
Nature. 2021 May;593(7860):586-590. doi: 10.1038/s41586-021-03539-7. Epub 2021 May 12. PubMed Article
Mao C, Liu X, Zhang Y, Lei G, Yan Y, Lee H, Koppula P, Wu S, Zhuang L, Fang B, Poyurovsky MV, Olszewski K, Gan B
Nature. 2021 May;593(7860):586-590. doi: 10.1038/s41586-021-03539-7. Epub 2021 May 12. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 186022 | lentiCRISPR v2-sgDHODH-4 | knock out DHODH in mammalian cells |
| 186023 | lentiCRISPR v2-sgDHODH-2 | knock out DHODH in mammalian cells |
| 186024 | lentiCRISPR v2-sgACSL4 | knock out ACSL4 in mammalian cells |
| 186025 | lentiCRISPR v2-sgCOQ2 | knock out COQ2 in mammalian cells |
| 186026 | lentiCRISPR v2-sgFSP1 | knock out FSP1 in mammalian cells |