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Addgene
The FusX TALE Base Editor (FusXTBE) for Rapid Mitochondrial DNA Programming of Human Cells In Vitro and Zebrafish Disease Models In Vivo.
Sabharwal A, Kar B, Restrepo-Castillo S, Holmberg SR, Mathew ND, Kendall BL, Cotter RP, WareJoncas Z, Seiler C, Nakamaru-Ogiso E, Clark KJ, Ekker SC
CRISPR J. 2021 Dec;4(6):799-821. doi: 10.1089/crispr.2021.0061. Epub 2021 Nov 30. PubMed Article

Plasmids from Article

ID Plasmid Purpose
196496ND4-FusXTBE-Left TALEExpresses left-side TALE-DddAtox Cterm half ND4-FusXTBE in mammalian cells
196497ND4-FusXTBE-Right TALEExpresses Right-side TALE-DddAtox Nterm half ND4-FusXTBE in mammalian cells
196498ND2-FusXTBE-Left TALEExpresses left-side TALE-DddAtox Cterm half ND2-FusXTBE in mammalian cells
196499ND2-FusXTBE-Right TALEExpresses Right-side TALE-DddAtox Nterm half ND2-FusXTBE in mammalian cells
196500Cox1-FusXTBE-Left TALEExpresses left-side TALE-DddAtox Cterm half Cox1-FusXTBE in mammalian cells
196501Cox1-FusXTBE-Right TALEExpresses Right-side TALE-DddAtox Nterm half Cox1-FusXTBE in mammalian cells
196502Cox1-FusXTBE-Left TALEExpresses left-side TALE–DddAtox N term half cox1-FusXTBE in zebrafish
196503Cox1-FusXTBE-RightTALEExpresses right-side TALE–DddAtox C term half cox1-FusXTBE in zebrafish
196504Cox3-FusXTBE-Left TALEExpresses left-side TALE–DddAtox N term half cox3-FusXTBE in zebrafish
196505Cox3-FusXTBE-RightTALEExpresses right-side TALE–DddAtox C term half cox3-FusXTBE in zebrafish
196506tl1-FusXTBE-Left TALEExpresses left-side TALE–DddAtox N term half tl1-FusXTBE in zebrafish
196507tl1-FusXTBE-RightTALEExpresses left-side TALE–DddAtox N term half tl1-FusXTBE in zebrafish
201397FusXTBE-1397-NExpresses N terminus half of DddAtox in mammalian cells
201398FusXTBE-1397-CExpresses C terminus half of DddAtox in mammalian cells

Antibodies from Article