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Base editing in human cells with monomeric DddA-TALE fusion deaminases.
Mok YG, Lee JM, Chung E, Lee J, Lim K, Cho SI, Kim JS
Nat Commun. 2022 Jul 12;13(1):4038. doi: 10.1038/s41467-022-31745-y. PubMed Article

Plasmids from Article

ID Plasmid Purpose
187409pCMV-AAAAA-nCas9(D10A)-UGIDddA AAAAA variant
187410pCMV-E1347A-nCas9(D10A)-UGIDddA E1347A variant
187411pCMV-UGI-nCas9(H840A)-GSVGDddA GSVG variant
187412pCMV-ND1 Left -GSVG-UGIhuman mitochondrial DNA ND1 target TALE
187413pCMV-ND1 Right-GSVG-UGIhuman mitochondrial DNA ND1 target TALE
187414pAAV-ND4 Right-GSVG-UGIhuman mitochondrial DNA ND4 target TALE
187415pAAV-ND4 Right-E1347A-UGIhuman mitochondrial DNA ND4 target TALE

Antibodies from Article